Tumour necrosis factor receptor deficiency alters anxiety-like behavioural and neuroendocrine stress responses of mice

Cytokine
Ulrike GimsaSaleh M Ibrahim

Abstract

Tumour necrosis factor (TNF)-alpha is known to be involved in anxiety and the regulation of the hypothalamic-pituitary-adrenal axis. To examine the role of its receptors in neuroendocrine immunomodulation, we studied behaviour, corticosterone production and T-cell activation in mice with a C57BL/6J background and deficient for one or both TNF receptors (TNFR1-/-, TNFR2-/-, and TNFR1+2-/-) compared to wildtype C57BL/6J mice with and without psychological stress. Stress was induced by social disruption (SDR), and anxiety-like behaviour was examined using the elevated plus maze (EPM). Anxiety of unstressed TNFR1+2-/- mice was increased compared to C57BL/6J mice as shown by reduced ratios of entries into open arms relatively to total entries. SDR-stressed TNFR1+2-/- mice showed reduced ratios of entries into open arms relatively to total entries, reduced ratios of distances walked in open relatively to distances walked in both arms and reduced time in open arms compared to C57BL/6J mice. Locomotor activity of unstressed and SDR-stressed TNFR1-/- and TNFR2-/- mice was reduced. Serum corticosterone concentrations of control mice do not differ between mouse strains. However, TNFR1+2-/- mice had significantly higher corticosterone conc...Continue Reading

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Citations

Jun 20, 2013·Behavioural Brain Research·Sira Díaz-MoránAlberto Fernández-Teruel
Jul 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Luana M ManossoAna Lúcia S Rodrigues
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pernille M MadsenKate L Lambertsen
Sep 28, 2021·Pharmacological Reports : PR·Frideriki PoutoglidouDimitrios Kouvelas

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