Tumour necrosis factor soluble receptors I and II and interleukin-1 receptor antagonist in acute pyelonephritis in relation to bacterial virulence-associated traits and renal function

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
S H JacobsonA Brauner

Abstract

Urinary tract infections activate both mucosal and systemic inflammatory responses reflected by elevation of cytokine concentrations in serum and urine. We determined urine and serum concentrations of tumour necrosis factor soluble receptors I and II (sTNFR I and sTNFR II) and interleukin-1 receptor antagonist (IL-1ra) in 41 women with acute pyelonephritis caused by Escherichia coli, 2 weeks after the infection, during a subsequent episode of cystitis or asymptomatic bacteriuria and also later when the same patients were free from bacteriuria. Concentrations of sTNFR I, sTNFR II and IL-1ra were related to the expression of five virulence markers of E. coli, glomerular filtration rate (GFR) and to the concentration of C-reactive protein (CRP) in serum. Patients with acute pyelonephritis had elevated serum concentrations of sTNFR I and sTNFR II compared to healthy women (P < 0.001 for both comparisons). The concentrations of sTNFR I and sTNFR II in urine were significantly higher in patients with acute pyelonephritis compared to controls (P < 0.001 in both cases). The concentration of sTNFR II in urine was higher in patients infected by E. coli producing haemolysin (P = 0.05) and in patients infected by E. coli expressing hydroph...Continue Reading

Citations

Feb 24, 2007·International Urology and Nephrology·Emmanouil GalanakisMaria Kalmanti
Nov 7, 2001·The Journal of Urology·O WitzkeU Heemann
Mar 11, 2011·Journal of Immunoassay & Immunochemistry·Yoshihiro OkamotoToshiyuki Masuzawa
Apr 23, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ashraf BakrRasha El-Ashry
Apr 6, 2006·Pediatrics·Emmanouil GalanakisMaria Kalmanti

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