Tumour necrosis factors in childhood asthma

Indian Journal of Pediatrics
F I NajamA H Shembesh

Abstract

Tumour necrosis factor-alpha (TNF alpha) and TNF beta levels in serum were measured by enzyme immunoassays in 64 Libyan children (age: 1-12 years, sex: 39 males, 25 females) with mild to moderately severe asthma (Group A). Among these patients, 35 had active disease (AA) and 29 had inactive disease (NA). According to age range, 20, 21 and 23 patients were between 1-3 years (A1), > 3-5 years (A2) and > 5-12 years (A3) respectively. A1 had 9 and 11 patients with active (AA1) and inactive (NA1) disease; A2 had 10 and 11 patients with active (AA2) and inactive (NA2) disease; A3 had 16 and 7 patients with active (AA3) and inactive (NA3) disease respectively. Age-matched comparisons was made with 57 healthy children (age: 1-12 years; sex: 30 males, 27 females) (Group B). Among the controls, 15, 19 and 23 children were between 1-3 years (B1), > 3-5 years (B2) and > 5-12 years (B3) respectively. It was observed that serum mean TNF alpha level was significantly higher in patients, while TNF beta levels was normal (A vs B-TNF alpha P < 0.001, TNF beta: P > 0.1). The TNF alpha level was elevated significantly in active disease, while it was normal in inactive disease (AA, NA, B: P = 0.0001; AA vs NA; P < 0.0001; NA vs B: P > 0.05) and TNF...Continue Reading

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Citations

Sep 28, 2005·Indian Journal of Pediatrics·F I E NajamA H Shembesh
Feb 19, 2011·Journal of Young Pharmacists : JYP·Kg PatelTr Gandhi
Jun 10, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S BoeroG A Rossi
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SilvestriF L M Ricciardolo
Mar 29, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hideshi KimotoHajime Kayanne
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Masayuki OkudaTatsuya Hobara

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