PMID: 2510784Jan 1, 1989Paper

Tumour pathology of the neuron-paraneuron system and its evolutionary background, with special attention to neuro-endocrine differentiation in prostate and mammary carcinomas

Archives of Histology and Cytology
S FalkmerJ M Nesland

Abstract

From results of phylogenetical investigations of the neuron-paraneuron or neuroendocrine system it is known that cells producing hormonal peptides appear first in the nervous system, then also as disseminated cells of an open or closed type in the mucosa of the alimentary tract, and, lastly, as the parenchyma of the classical endocrine glands. In all these three parts of the neuroendocrine system the parenchymal cells can undergo neoplastic transformation, expressing "eutopic" and/or "ectopic" peptide hormones and/or biogenic amines. The neuro-paraneuronal tumours arising in the central or peripheral nervous system in man are rare. In contrast, they are more common when they originate from the disseminated neuroendocrine cells in the gut mucosa, and when they arise in the endocrine glands. Here, a broad spectrum of histopathologically benign or malignant neoplasms, hyperplastic nodules, and other tumour-like lesions occur, some of which are associated with well-known clinicopathological entities. Typical examples are the gastrointestinal carcinoids, pancreatic insulomas, pituitary adenomas, medullary thyroid carcinomas, and phaeochromocytomas. The fact that neoplastically transformed cells of some traditionally non-endocrine tu...Continue Reading

Citations

Feb 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D MackO Dietze
May 22, 2003·Progress in Histochemistry and Cytochemistry·Luis M MontuengaAna C Villaro
Apr 12, 2002·The Prostate·Hazem R Ismail ASimone Chevalier
Jan 1, 1994·Ultrastructural Pathology·R A Erlandson, J M Nesland

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