Tumour reducing and anticarcinogenic activity of selected spices

Cancer Letters
M C Unnikrishnan, R Kuttan

Abstract

Tumour reducing activity of extracts of eight commonly used spices in India were studied in mice transplanted intraperitoneally with Ehrlich ascites tumour. Oral administration of extracts of black pepper, asafoetida, pippali and garlic could increase the percentage of life span in these mice by 64.7%, 52.9%, 47% and 41.1%, respectively. However intraperitoneal administration of spice extracts did not produce any significant reduction in tumour growth except for sesame (38.8%). Garlic extract and asafoetida extracts also inhibited two stage chemical carcinogenesis induced by 7,12 dimethyl benzanthracene and croton oil on mice skin with significant reduction in papiloma formation. These results indicate the potential use of spices as anti-cancer agents as well as anti-tumour promoters.

References

Jan 1, 1988·Nutrition and Cancer·M C Unnikrishnan, R Kuttan
Nov 1, 1985·Cancer Letters·R KuttanM C George

❮ Previous
Next ❯

Citations

Jul 1, 1995·World Journal of Surgery·J Y ChengJ C Lin
Feb 1, 1995·Pharmacology & Therapeutics·M McLean, M F Dutton
Mar 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y J Surh, S S Lee
Mar 7, 1998·Cancer Letters·P V Mohanan, K S Devi
Aug 30, 2003·Fitoterapia·K G Nevin, P L Vijayammal
Nov 8, 2007·Critical Reviews in Food Science and Nutrition·K Srinivasan
Oct 12, 2012·Pharmacognosy Reviews·Poonam Mahendra, Shradha Bisht
Dec 20, 2011·Preventive Medicine·Sahdeo PrasadBharat B Aggarwal
Apr 30, 2013·Phytotherapy Research : PTR·Murlidhar Meghwal, T K Goswami
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Yong ZhangJunxuan Lü
Dec 7, 2010·Journal of Ethnopharmacology·Milad Iranshahy, Mehrdad Iranshahi
Dec 11, 2008·Phytotherapy Research : PTR·Venkatraman MageshDhanapal Sakthisekaran
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edward W HowardYong Chuan Wong
Apr 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P LaohavechvanichA J Ketterman
Dec 20, 1999·Journal of Agricultural and Food Chemistry·Y IkkenM I Cambero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.