Tumour size can have an impact on the outcomes of epidemiological studies on second cancers after radiotherapy

Radiation and Environmental Biophysics
Uwe SchneiderWayne Newhauser

Abstract

Obtaining a correct dose-response relationship for radiation-induced cancer after radiotherapy presents a major challenge for epidemiological studies. The purpose of this paper is to gain a better understanding of the associated uncertainties. To accomplish this goal, some aspects of an epidemiological study on breast cancer following radiotherapy of Hodgkin's disease were simulated with Monte Carlo methods. It is demonstrated that although the doses to the breast volume are calculated by one treatment plan, the locations and sizes of the induced secondary breast tumours can be simulated and, based on these simulated locations and sizes, the absorbed doses at the site of tumour incidence can also be simulated. For the simulations of point dose at tumour site, linear and non-linear mechanistic models which predict risk of cancer induction as a function of dose were applied randomly to the treatment plan. These simulations provided for each second tumour and each simulated tumour size the predicted dose. The predicted-dose-response-characteristic from the analysis of the simulated epidemiological study was analysed. If a linear dose-response relationship for cancer induction was applied to calculate the theoretical doses at the s...Continue Reading

References

Aug 8, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wolfgang Dörr, Thomas Herrmann
Jul 24, 2003·JAMA : the Journal of the American Medical Association·Lois B TravisEthel Gilbert
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Uwe SchneiderBarbara Kaser-Hotz
Apr 16, 2005·Zeitschrift für medizinische Physik·Uwe Schneider, Barbara Kaser-Hotz
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Ibrahima DialloFlorent de Vathaire
Dec 8, 2009·Molecular and Cellular Endocrinology·Horst ZitzelsbergerKristian Unger
Nov 16, 2010·Physics in Medicine and Biology·Rebecca M HowellDerek Z Yaldo
Mar 4, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·X Sharon QiX Allen Li
Dec 3, 2013·Zeitschrift für medizinische Physik·Uwe SchneiderJürgen Besserer
Sep 13, 2016·Nature Communications·Sam BehjatiPeter J Campbell
Apr 2, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Uwe Schneider, Linda Walsh

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Citations

Jul 19, 2021·Radiation and Environmental Biophysics·Cristoforo SimonettoMarkus Eidemüller

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