Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

European Journal of Epidemiology
Emanuele LeonciniStefania Boccia

Abstract

Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium-Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52-67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41-2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24-0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00-1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13-3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC ...Continue Reading

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Citations

Nov 22, 2019·Head & Neck·Andrés Coca-PelazAlfio Ferlito
Mar 5, 2020·Laryngoscope Investigative Otolaryngology·Carol R BradfordAlessandra Rinaldo
Jun 23, 2020·Oral Diseases·Francesca BraviUNKNOWN INHANCE Consortium investigators
Jul 2, 2020·Clinical Oral Investigations·Anthony ValentinSebastian Hoefert
Jul 28, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Huafu LiChanghua Zhang
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Nov 30, 2019·Head & Neck·Allison MarzilianoMichael A Diefenbach
Feb 20, 2020·Oral Diseases·Jasper VonkMax Johannes Hendrikus Witjes
Oct 22, 2020·Disease Markers·Gabriella CadoniGiovanni Almadori
Feb 9, 2021·World Journal of Clinical Cases·Min ChenHai-Tao Wu
Jan 17, 2022·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xiushuai DuJin Liu

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