Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.

Immunology
Rong YangJiang Li

Abstract

The expansion of myeloid-derived suppressor cells (MDSCs) correlates with tumorigenesis in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC number and Yes-associated protein 1 (YAP1) and phosphatase and tensin homologue (PTEN) levels in CRC patients (P < 0·05). Moreover, the CD33+ MDSCs, YAP1 and PTEN were identified as predictors for the prognosis of CRC patients (P < 0·05). Notably, CD33+ MDSCs were an independent survival predictor for CRC patients through a Cox model analysis. In vitro data determined that the expression levels of YAP1 and PTEN in CRC-derived cell lines were associated with CRC-derived MDSC induction, and the blockade of YAP1 and PTEN decreased CRC-derived MDSC induction. A mechanistic analysis revealed that YAP1 promoted CRC-derived MDSC induction by suppressing PTEN expression to up-regulate COX-2, P-AKT and P-p65 in CRC-derived cells, leading to secretion of the cytokine granulocyte-macrophage colony-stimulating factor. Our findings establish a novel mechanism of pro-tumorigenic MDSC induction mediated by ectopic YAP1 and PTEN expression in CRC.

References

Feb 17, 2007·Current Opinion in Immunology·François GhiringhelliLaurence Zitvogel
Jun 9, 2010·The Cancer Journal·Peter M WilsonHeinz-Josef Lenz
Feb 18, 2012·The Journal of Biological Chemistry·Wesley M KonsavageGregory S Yochum
Apr 26, 2012·British Journal of Cancer·A LugliI Zlobec
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang LiuQingqing Wang
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Jan 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Limin LiKe Zen
Apr 30, 2014·Cancer Research·Darya Alizadeh, Nicolas Larmonier
May 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mohammad AtefiAntoni Ribas
Jul 1, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Kun LiangCuiping Zhang
Jul 15, 2015·The Journal of Clinical Investigation·Douglas Marvel, Dmitry I Gabrilovich
Dec 10, 2015·Cancer Discovery·Weiyi PengPatrick Hwu
Dec 25, 2015·Cancer Discovery·Guocan WangRonald A DePinho
Aug 4, 2016·Chinese Journal of Cancer·Wanqing ChenSiwei Zhang

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Citations

Dec 13, 2018·BioMed Research International·Luo ZhangJingting Jiang
Apr 25, 2020·British Journal of Cancer·Thiago VidottoJeremy A Squire
Jul 17, 2019·Molecular Cancer Research : MCR·Zhaoji PanGuoping Niu
Jul 3, 2021·Cancers·Giampaolo MorcianoCarlotta Giorgi

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