Tumours arising in the setting of paediatric chronic epilepsy

Pathology
Richard A Prayson

Abstract

Along with malformations of cortical development or cortical dysplasia, hippocampal sclerosis, and remote ischaemic damage, tumours are among the more commonly identifiable causes of medically intractable seizures in paediatric age patients. This study reviews one institution's 20 year experience with tumours arising in this clinical setting. Retrospective review of 129 paediatric patients [less than 19 years of age, 65 females (50.4%)] with tumours and medically intractable seizures encountered during a 20 year period of time (1989-2009). Using the most recent World Health Organization (WHO) classification of brain tumours, tumour type and grade were assessed. The most common sites of origin included temporal lobe (n = 77, 59.7%), parietal lobe (n = 20, 15.5%), and frontal lobe (n = 15, 11.6%). WHO grade included 73 (56.6%) grade I tumours, 32 (24.8%) grade II tumours, and 18 (14%) grade I/II tumours. In six cases (4.7%), a WHO grade was not associated with mass. Tumour types included: ganglioglioma (n = 48, 37.2%), dysembryoplastic neuroepithelial tumour (n = 17, 13.2%), low grade astrocytoma (n = 15, 11.6%), low grade mixed glioma (n = 8, 6.2%), low grade oligodendroglioma (n = 5, 3.9%), meningioangiomatosis (n = 4, 3.1%) an...Continue Reading

References

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Citations

Oct 30, 2013·Disease Markers·Ana Paula Toledo Del RioManoel Barros Bertolo
Dec 12, 2012·Journal of Neurosurgery. Pediatrics·Micol BabiniFabio Calbucci
Feb 5, 2013·Journal of Radiology Case Reports·Hector N AguilarTrevor Kotylak
Mar 14, 2012·Future Oncology·Shiyong LiuHui Yang
Jun 21, 2015·Journal of Neuroscience Methods·Timo Kirschstein, Rüdiger Köhling
Apr 14, 2012·Brain Pathology·Maria ThomEleonora Aronica
Jul 17, 2015·Journal of Korean Neurosurgical Society·Kouji YamasakiHideo Takeshima
Mar 5, 2014·Biochimica Et Biophysica Acta·Guillaume BergtholdMark W Kieran
Jul 17, 2012·Annals of Diagnostic Pathology·Richard A Prayson
Jan 17, 2015·Neurology India·Aanchal KakkarChitra Sarkar
Oct 21, 2016·World Neurosurgery·Lain Hermes Gonzalez-QuaranteEmma Sola Vendrell
Sep 20, 2012·Arquivos de neuro-psiquiatria·Diego Cassol DozzaLeila Chimelli
May 26, 2012·Journal of Child Neurology·Aviva Fattal-ValevskiShlomi Constantini
Sep 16, 2011·American Journal of Clinical Pathology·Richard A Prayson
Aug 10, 2018·Journal of Epilepsy Research·Sangjoon ChongSeung-Ki Kim
Dec 19, 2013·Experimental and Therapeutic Medicine·Guoqiang ChenYulan Jin
Nov 19, 2014·World Journal of Clinical Cases·Marco GiulioniGuido Rubboli

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