Tumours may be innervated

Virchows Archiv : an International Journal of Pathology
P Seifert, Manfred Spitznas

Abstract

It is generally assumed that tumours are not innervated. However, following an accidental observation of a nerve fibre within an adenoma of the ciliary body epithelium of the eye, we have further examined two such tumours. One pigmented and one non-pigmented adenoma of the ciliary body epithelium (APCE and ANCE, respectively) that had been surgically removed from two human eyes were processed for ultrastructural evaluation and systematically screened and analysed for the occurrence of nerve tissue under a transmission electron microscope. The adenomas were composed of epithelial tumour cell strands and interposed vascularised connective tissue. Both tumours contained a small number of fine unmyelinated nerve fibres containing clear and dense core vesicles. In both adenomas, the nerve fibres were located in the tumour periphery close to blood vessels and tumour cells. In the APCE, they were also seen in more central areas. Since nerves always have a function, this finding, if confirmed in other neoplasms, may influence our understanding of such innervated tumours.

Citations

Dec 26, 2007·Pathology Oncology Research : POR·Aping YuanGuanglin Cui
Apr 9, 2005·Experimental Neurology·Christopher M PetersPatrick W Mantyh
Jul 31, 2003·Medical Hypotheses·E Lundsgaard
May 7, 2002·Nature Reviews. Cancer·Patrick W MantyhSteve P Hunt
May 22, 2008·British Journal of Anaesthesia·A DelaneyM Fallon
May 7, 2002·American Journal of Ophthalmology·Peter Seifert, Manfred Spitznas
May 28, 2011·Biochimica Et Biophysica Acta·Mario MancinoVanessa Almendro
Mar 13, 2003·World Journal of Gastroenterology : WJG·Shuang-Hong LüShao-Jun Liu
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Meike KörnerJean Claude Reubi
Apr 20, 2013·Oncology Letters·Sha LiDongwei Gao
Jan 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R ShurinYuri L Bunimovich
Mar 7, 2021·Cells·Michael R ShurinGalina V Shurin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Virchows Archiv : an International Journal of Pathology
Peter SeifertPeter Effert
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
J T JenkinsJ R McGregor
© 2021 Meta ULC. All rights reserved