Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Gyde NissenMarkus Weckmann

Abstract

Asthma is a chronic inflammatory disease with structural changes present. Burgess and colleagues recently found tumstatin markedly reduced in adult asthmatic lung tissue compared with nonasthmatics. ECM fragments such as tumstatin are named matrikines and act independently of the parent molecule. The role of Col IV matrikines in neutrophil inflammation (eg. exacerbation in asthma) has not been investigated to date. Severe adult asthma phenotypes are dominated by neutrophilic inflammation and show a high frequency of severe exacerbations. This study sought to investigate the role of a novel active region within tumstatin (CP17) and its implication in neutrophil inflammatory responses related to asthma exacerbation. For reactive oxygen production, isolated neutrophils were preincubated with peptides or vehicle for 1 hour and stimulated (PMA). Luminescence signal was recorded (integration over 10 seconds) for 1.5 hours. Neutrophil migration was performed according to the SiMA protocol. Mice were sensitized to OVA/Alumn by intraperitoneal (i.p.) injections. Mice were then treated with CP17, vehicle (PBS) or scrambled peptide (SP17) after OVA exposure (days 27 and 28, polyI:C stimulation). All animals were killed on day 29 with lung...Continue Reading

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Citations

May 19, 2020·Alimentary Pharmacology & Therapeutics·Ida Falk VillesenMette Juul Nielsen
Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJudith A Woodfolk
May 16, 2020·Frontiers in Immunology·Andreas FreyMichael Wegmann
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shiwen LiuC Yan Cheng
Jun 11, 2021·ERJ Open Research·Sai Sneha Priya NemaniMarkus Weckmann
Jun 12, 2021·Immunity, Inflammation and Disease·Richard F KrausMartin Kieninger
Sep 21, 2021·Clinical Reviews in Allergy & Immunology·Luiz Otávio LourençoCarla Máximo Prado
Jul 31, 2021·The European Respiratory Journal·Markus WeckmannUNKNOWN ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)

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