Tunable diffusive lateral inhibition in chemical cells

The European Physical Journal. E, Soft Matter
Ning LiSeth Fraden

Abstract

The Belousov-Zhabotinsky (BZ) reaction has become the prototype of nonlinear chemical dynamics. Microfluidic techniques provide a convenient method for emulsifying BZ solutions into monodispersed drops with diameters of tens to hundreds of microns, providing a unique system in which reaction-diffusion theory can be quantitatively tested. In this work, we investigate monolayers of microfluidically generated BZ drops confined in close-packed two-dimensional (2D) arrays through experiments and finite element simulations. We describe the transition from oscillatory to stationary chemical states with increasing coupling strength, controlled by independently varying the reaction chemistry within a drop and diffusive flux between drops. For stationary drops, we studied how the ratio of stationary oxidized to stationary reduced drops varies with coupling strength. In addition, using simulation, we quantified the chemical heterogeneity sufficient to induce mixed stationary and oscillatory patterns.

References

Aug 30, 2008·Angewandte Chemie·Masahiro ToiyaIrving R Epstein
Sep 25, 2008·Lab on a Chip·C HoltzeD A Weitz
Aug 31, 2010·Trends in Cell Biology·Hernan G GarciaRob Phillips
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Vladimir K Vanag, Irving R Epstein
Jul 14, 2012·Trends in Cell Biology·Keiko U Torii
Mar 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nathan TompkinsSeth Fraden
Apr 29, 2014·Physical Chemistry Chemical Physics : PCCP·Ning LiSeth Fraden

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Citations

Jun 29, 2015·Chaos·Nathan TompkinsSeth Fraden
Aug 16, 2017·Physical Chemistry Chemical Physics : PCCP·Valérie VoorsluijsYannick De Decker
Jun 2, 2018·Physical Chemistry Chemical Physics : PCCP·Ivan S Proskurkin, Vladimir K Vanag
Jan 4, 2018·Lab on a Chip·Thomas LitschelSeth Fraden
Mar 23, 2021·Frontiers in Cellular Neuroscience·Andrey Yu VerisokinAlexey R Brazhe
Dec 15, 2020·The Journal of Physical Chemistry. B·James SheehySeth Fraden

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