Tunable drug delivery using chemoselective functionalization of hydrogels

Materials Science & Engineering. C, Materials for Biological Applications
Emanuele MauriAlessandro Sacchetti

Abstract

In the last decades interests on cleavable linkers are growing due to the need to develop controlled drug delivery systems in biochemical and therapeutic applications. The synthesis of hydrogels as devices capable to maintain the drug level within a desired range for a long and sustained period of time is a leading strategy for this aim. However with respect to the good results obtained with antibodies and peptides there are a lot of problems related to the quick and uncontrolled diffusion of small molecules through hydrogel pores. In this work, we propose the functionalization of polyethylene glycol (PEG) chains with two different pH-sensitive linkers, ester and hydrazone, and their application as building blocks of microwave-assisted hydrogels for controlled delivery of small hydrophilic drugs. As drug mimetic we used Rhodamine B, a harmless fluorophore with steric hindrance and reactive groups similar to many small hydrophilic drugs. At physiological and low basic conditions, the cleavability of ester and hydrazone spacer evidenced the possibility to delay the release of drugs from the scaffold compared to hydrogels where drug was entrapped within the network only due to its steric hindrance. The obtained release profiles we...Continue Reading

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Citations

Jan 21, 2017·Expert Opinion on Drug Delivery·Emanuele MauriFilippo Rossi
Jan 26, 2018·Biomaterials Science·Emanuele MauriStefano Pluchino
Sep 16, 2020·International Journal of Molecular Sciences·Filippo PinelliFilippo Rossi
May 19, 2020·Expert Opinion on Biological Therapy·Simonetta PapaFilippo Rossi
Mar 7, 2021·Carbohydrate Polymers·Olivier FourmannGilberto Siqueira
Aug 2, 2021·International Journal of Pharmaceutics·Matteo MaraldiDavide Moscatelli

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