Tunable graphene quantum point contact transistor for DNA detection and characterization

Nanotechnology
Anuj GirdharJean-Pierre Leburton

Abstract

A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration influences the membrane conductance caused by the electrostatic interaction between the DNA nucleotides and the nanopore edge. It is shown that the graphene conductance variations resulting from DNA translocation can be enhanced by choosing a particular geometry as well as by modulating the graphene Fermi energy, which demonstrates the ability to detect conformational transformations of a double-stranded DNA, as well as the passage of individual base pairs of a single-stranded DNA molecule through the nanopore.

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Citations

Dec 31, 2016·The Journal of Physical Chemistry. B·Aditya SarathyJean-Pierre Leburton
Feb 6, 2018·NPJ 2D Materials and Applications·Hu QiuJean-Pierre Leburton
Oct 17, 2020·The Journal of Physical Chemistry. B·Aodong ZouRuhong Zhou
Apr 18, 2018·ACS Sensors·Nagendra Bala Murali AthreyaJean-Pierre Leburton
Jan 8, 2021·The Journal of Physical Chemistry Letters·Changxiong HuangJun Fan

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