Tuning Nano-Amorphous Calcium Phosphate Content in Novel Rechargeable Antibacterial Dental Sealant

Materials
Maria Salem IbrahimMary Anne Sampaio de Melo

Abstract

Dental sealants with antibacterial and remineralizing properties are promising for caries prevention among children and adolescents. The application of nanotechnology and polymer development have enabled nanoparticles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM) to emerge as anti-caries strategies via resin-based dental materials. Our objectives in this study were to (1) incorporate different mass fractions of NACP into a parental rechargeable and antibacterial sealant; (2) investigate the effects on mechanical performance, and (3) assess how the variations in NACP concentration would affect the calcium (Ca) and phosphate (PO₄) ion release and re-chargeability over time. NACP were synthesized using a spray-drying technique and incorporated at mass fractions of 0, 10, 20 and 30%. Flexural strength, flexural modulus, and flowability were assessed for mechanical and physical performance. Ca and PO₄ ion release were measured over 70 days, and three ion recharging cycles were performed for re-chargeability. The impact of the loading percentage of NACP upon the sealant's performance was evaluated, and the optimized formulation was eventually selected. The experimental sealant at 20% NACP had ...Continue Reading

References

Aug 26, 2006·Journal of Dental Research·L M A TenutaJ A Cury
Mar 4, 2008·The Journal of the American Dental Association·Jean BeauchampUNKNOWN American Dental Association Council on Scientific Affairs
Oct 27, 2009·Brazilian Oral Research·Jaime Aparecido Cury, Livia Maria Andaló Tenuta
Feb 8, 2011·Lancet·Habib BenzianJudith Mackay
Aug 31, 2012·Journal of Dental Research·M D WeirH H K Xu
Nov 10, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Mary Anne S MeloHockin H K Xu
Nov 13, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Mary Anne S MeloHockin H K Xu
Jan 3, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mary Anne S MeloHockin H K Xu
Jul 3, 2013·Trends in Biotechnology·Mary A S MeloLidiany K A Rodrigues
Feb 19, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Fang LiHockin H K Xu
Jul 19, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Ning ZhangHockin H K Xu
Jan 9, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Ling ZhangHockin H K Xu
Apr 16, 2016·ACS Applied Materials & Interfaces·Mary Anne Sampaio de MeloDwayne D Arola
Nov 5, 2016·International Journal of Oral Science·Xian-Ju XieHockin Hk Xu
Mar 11, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mary A S MeloHockin H K Xu
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Anneli Ahovuo-SalorantaHelen V Worthington

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Citations

Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenjing Song, Shaohua Ge
Jul 1, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maria Salem IbrahimMary Anne S Melo
Jun 13, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Abdulrahman A BalhaddadMary Anne S Melo
Apr 4, 2021·Materials·Alexandrina MunteanAda Gabriela Delean
Apr 21, 2021·Stomatologii︠a︡·A V Blinova, V A Rumyantsev

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