Tuning of major signaling networks (TGF-β, Wnt, Notch and Hedgehog) by miRNAs in human stem cells commitment to different lineages: Possible clinical application

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Sedigheh Fekri AvalNosratollah Zarghami

Abstract

Two distinguishing characteristics of stem cells, their continuous division in the undifferentiated state and growth into any cell types, are orchestrated by a number of cell signaling pathways. These pathways act as a niche factor in controlling variety of stem cells. The core stem cell signaling pathways include Wingless-type (Wnt), Hedgehog (HH), and Notch. Additionally, they critically regulate the self-renewal and survival of cancer stem cells. Conversely, stem cells' main properties, lineage commitment and stemness, are tightly controlled by epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA-mediated regulatory events. MicroRNAs (miRNAs) are cellular switches that modulate stem cells outcomes in response to diverse extracellular signals. Numerous scientific evidences implicating miRNAs in major signal transduction pathways highlight new crosstalks of cellular processes. Aberrant signaling pathways and miRNAs levels result in developmental defects and diverse human pathologies. This review discusses the crosstalk between the components of main signaling networks and the miRNA machinery, which plays a role in the context of stem cells development and provides a set of examples to illustr...Continue Reading

Citations

Jul 15, 2017·International Journal of Molecular Sciences·Ammad Ahmad FarooqiHsueh-Wei Chang
Apr 27, 2019·Journal of Cellular Physiology·Zahra BahmanpourSima Mansoori Derakhshan
Mar 15, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhiwei HeChengyi Sun
Oct 2, 2019·Current Molecular Medicine·Roghayeh SheervalilouNosratollah Zarghami
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Naizhen ZhouTianzhu Zhang
Aug 10, 2021·International Immunopharmacology·Wenyan ChenGuanghong Yang
Sep 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh MemariNosratollah Zarghami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.