Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels

Advanced Healthcare Materials
Stacey C SkaalureStephanie J Bryant

Abstract

Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.

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Citations

Jun 15, 2017·Soft Matter·Shankar Lalitha SridharFranck J Vernerey
Feb 9, 2019·Advanced Healthcare Materials·Nureddin AshammakhiAli Khademhosseini
Apr 16, 2016·Annals of Biomedical Engineering·Luke D Amer, Stephanie J Bryant
Oct 5, 2017·Advanced Healthcare Materials·Stephanie J Bryant, Franck J Vernerey
Feb 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marja B PimentelGeorgia Papavasiliou
Mar 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Margaret C SchneiderStephanie J Bryant
Sep 18, 2020·Tissue Engineering. Part a·Shalini V GohilLakshmi S Nair
Jul 28, 2017·Journal of the Royal Society, Interface·Franck Vernerey, Tong Shen
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Tingting YuBing Han
Jan 24, 2020·Bulletin of Mathematical Biology·Simone Cassani, Sarah D Olson
Sep 3, 2021·Chemical Reviews·Franck J VernereyStephanie J Bryant

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