Tuning synapses by proteolytic remodeling of the adhesive surface

Current Opinion in Neurobiology
Toru Shinoe, Yukiko Goda

Abstract

Cell adhesion molecules (CAMs) play a crucial role in organizing the synaptic interface and regulating synapse activity. In turn, CAMs can influence a variety of higher brain functions. In addition to their bona fide interacting partners on the apposed cell surface or the extracellular matrix (ECM) with which they form molecular bridges, synaptic CAMs bind to many other proteins with their intracellular and extracellular domains. The resulting multi-molecular complexes at the active zone and at the postsynaptic density (PSD) are thought to anchor components requisite for synaptic transmission. Recent studies demonstrating the proteolytic cleavage of synaptic CAMs underscore an exciting mechanism through which the synaptic microenvironment can be altered and thereby finely tune the efficacy of synaptic transmission.

References

Apr 11, 2002·Nature Cell Biology·Cindy K Miranti, Joan S Brugge
Apr 3, 2003·Nature Reviews. Neuroscience·Daniel Choquet, Antoine Triller
Oct 2, 2003·Current Opinion in Cell Biology·Masahito YamagataJoshua A Weiner
Jun 11, 2004·Nature·Masanori MatsuzakiHaruo Kasai
Sep 15, 2004·Current Opinion in Cell Biology·Joni D Mott, Zena Werb
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sara MoneaEdward B Ziff
Mar 28, 2007·Journal of Neuroscience Research·Iryna M Ethell, Douglas W Ethell
May 8, 2007·Neuron·Laura SagliettiMaria Passafaro
May 12, 2007·Journal of Neurophysiology·Ozlem BozdagiGeorge W Huntley
Jun 8, 2007·Neuron·Chin-Yin TaiErin M Schuman
Apr 12, 2008·Science·Martin HeineDaniel Choquet
Apr 22, 2008·Nature Reviews. Neuroscience·Lorenzo A Cingolani, Yukiko Goda
Jul 8, 2008·Current Opinion in Cell Biology·Chin-Yin TaiErin M Schuman
Aug 8, 2008·Trends in Neurosciences·Jyothi Arikkath, Louis F Reichardt
Aug 21, 2009·Nature Reviews. Neuroscience·Anthony Holtmaat, Karel Svoboda
Feb 9, 2010·Trends in Neurosciences·Haruo KasaiJun Noguchi
Mar 5, 2010·Journal of Cell Science·John J E ChuaReinhard Jahn
Apr 7, 2010·Annual Review of Neuroscience·Kang Shen, Peter Scheiffele
May 5, 2010·The Journal of Cell Biology·Pablo MendezDominique Muller
Sep 14, 2010·Current Opinion in Neurobiology·Tabrez J Siddiqui, Ann Marie Craig
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Inga U SchapitzMatthias Kneussel
Oct 1, 2010·Hippocampus·Deanna L Benson, George W Huntley
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matteo MalinvernoFabrizio Gardoni
Jan 25, 2011·Current Opinion in Neurobiology·G Stefano Brigidi, Shernaz X Bamji
Mar 1, 2011·Neuroscience Research·Andrew B McGeachieYukiko Goda
Nov 3, 2011·Cold Spring Harbor Perspectives in Biology·Morgan Sheng, Eunjoon Kim
Apr 27, 2012·Physiological Reviews·Shinji Hirano, Masatoshi Takeichi
Jun 21, 2012·Nature Reviews. Neuroscience·Pico CaroniDominique Muller
Jul 4, 2012·The European Journal of Neuroscience·A B McGeachieY Goda
Oct 11, 2012·Nature Reviews. Neuroscience·George W Huntley
Oct 23, 2012·Neuron·Kunimichi SuzukiTakeshi Iwatsubo
Dec 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elaine C BudreckJoung-Hun Kim
Aug 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepak NairJean-Baptiste Sibarita
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ewelina KnapskaLeszek Kaczmarek
Mar 4, 2014·Nature Neuroscience·Ulrike PannaschNathalie Rouach
May 23, 2014·Frontiers in Neuroanatomy·Chia-Chien ChenYi Zuo

❮ Previous
Next ❯

Citations

May 14, 2016·Trends in Neurosciences·Patrick J MulhollandPeter W Kalivas
Nov 1, 2016·Journal of Neurochemistry·Behnam VafadariLeszek Kaczmarek
Nov 5, 2016·Nature Reviews. Neuroscience·Yun Kyung Park, Yukiko Goda
Nov 26, 2015·Development·Mary Lynn DearKendal Broadie
Oct 10, 2018·Frontiers in Cell and Developmental Biology·Adam Gorlewicz, Leszek Kaczmarek
Dec 15, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Raphael Vezina-AudetteSalvatore Carbonetto
Nov 3, 2017·Neuron·Thomas BiedererThomas A Blanpied

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Current Opinion in Neurobiology
G Stefano Brigidi, Shernaz X Bamji
Progress in Brain Research
Meghan E KerriskAnthony J Koleske
Advances in Experimental Medicine and Biology
Martin Heine
Molecular and Cellular Neurosciences
Shigeo Okabe
© 2021 Meta ULC. All rights reserved