Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation.

Chemical Communications : Chem Comm
Emily R CrossDave J Adams

Abstract

We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine. Dopamine undergoes oxidation in air, reducing the pH to induce gelation. The production of polydopamine and release of reactive oxygen species such as hydrogen peroxide confers antimicrobial activity. Gel stiffness can be controlled by modulating the initial starting pH of the gelator solution. We can use this method to tune the antimicrobial activity of the gels, with gels that are less stiff demonstrating increased bactericidal efficacy against Gram-positive bacteria.

References

Jan 1, 1976·Journal of Medicinal Chemistry·D C TseR N Adams
Jan 1, 1995·Chemical Research in Toxicology·R V Lloyd
Apr 17, 1999·Science·C Potera
Feb 20, 2002·Chemical Reviews·Pierre Terech, Richard G. Weiss
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A Pankey, L D Sabath
Apr 16, 2004·Clinical Microbiology Reviews·Erna M Kojic, Rabih O Darouiche
Aug 18, 2006·The Journal of Physical Chemistry. B·Ales PanacekRadek Zboril
Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Jun 21, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Juan Francisco Hernández-SierraGabriel Martínez Castañón
Apr 28, 2011·Journal of Biomedical Materials Research. Part a·Huanan LiXingdong Zhang
May 10, 2013·Nature Biotechnology·Jeffrey L Fox
Oct 15, 2013·Biopolymers·Ana Salomé Veiga, Joel P Schneider
Apr 29, 2014·Cell·Etienne Maisonneuve, Kenn Gerdes
Jan 15, 2015·Biomacromolecules·Tong-Fei Wu, Jong-Dal Hong
Oct 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Weichao ZhengZhaoxia Jin
Mar 1, 2016·ACS Infectious Diseases·Helen I ZgurskayaS Gnanakaran
May 6, 2016·Chemical Communications : Chem Comm·Emily R DraperDave J Adams
Aug 11, 2016·MBio·Joris van der HeijdenB Brett Finlay
Jun 21, 2017·Biomacromolecules·Laura L E MearsDave J Adams
Sep 28, 2017·PloS One·Hairuo WenLiming Xu
May 23, 2018·The Journal of Physical Chemistry. B·Mikko SalomäkiJukka Lukkari
Jun 8, 2018·Advanced Science·Shuqiang LiXuesi Chen
Jun 27, 2018·Journal of the American Chemical Society·Emily R CrossDave J Adams
Sep 5, 2018·Journal of Orthopaedic Surgery and Research·Chenhao PanXiaowei Yu
Nov 1, 1996·Journal of Food Protection·Benjamin J Juven, Merle D Pierson
Oct 15, 2019·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chun-Hsing LiaoChih-Hung Chang

❮ Previous
Next ❯

Citations

Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Galit Fichman, Joel P Schneider

❮ Previous
Next ❯

Methods Mentioned

BETA
rheology
small angle neutron scattering

Software Mentioned

SasView

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.