Turbina oblongata Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions.

Frontiers in Pharmacology
Ochuko L ErukainureMd Shahidul Islam

Abstract

Cardiotoxicity leading to cardiovascular dysfunction and ultimately cardiac failure remains a major global health issue irrespective of race, age and country. Several factors including lipotoxicity, oxidative imbalance, exacerbated angiotensin-converting enzyme (ACE) activity and altered bioenergetics have been implicated in the pathophysiology of cardiovascular diseases. Turbina oblongata (E. Mey. ex Choisy) A. Meeuse is among the medicinal plants commonly used traditionally in the treatment and management of various ailments including cardiovascular dysfunctions in South Africa. In the present study, T. oblongata was investigated for its cardioprotective mechanism on oxidative-mediated cardiotoxicity by determining its effect on redox imbalance, purinergic and cholinergic dysfunction, and ACE activity as well as lipid dysmetabolism and pathways in iron-induced oxidative cardiac injury. Oxidative injury was induced ex vivo in freshly isolated heart by incubating with 0.1 mM FeSO4. Treatment was done by co-incubating with T. oblongata extract or gallic acid which served as the standard antioxidant. Induction of oxidative cardiac injury led to significant depleted levels of glutathione, triglyceride, HDL-cholesterol, superoxide,...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·B HolmquistJ F Riordan
Jun 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K G LampingD D Heistad
Aug 1, 1997·Cardiovascular Research·C Antozzi, M Zeviani
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F FiordalisoJ Kajstura
May 29, 2002·Cardiovascular Research·José Marín-García, Michael J Goldenthal
Apr 16, 2003·Heart·N Poulter
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Dec 9, 2003·The Journal of Physiology·Renée Ventura-ClapierVladimir Veksler
Jan 15, 2005·Journal of Applied Physiology·D L KelloggJ V Green
Jan 26, 2005·Basic & Clinical Pharmacology & Toxicology·Suvara K WattanapitayakulJohn A Bauer
Jul 26, 2005·Acta Pharmacologica Sinica·Loren E WoldJun Ren
Jun 21, 2006·The American Journal of Cardiology·Carlos M Ferrario, William B Strawn
Jun 2, 2009·Journal of Molecular and Cellular Cardiology·Ian M Fearon, Stephen P Faux
Sep 25, 2009·American Journal of Physiology. Renal Physiology·Libor KopkanDewan S A Majid
Jul 30, 2010·Journal of Ethnopharmacology·Young Sook KimJin Sook Kim
Sep 3, 2010·The Journal of Physiology·Brett S KirbyFrank A Dinenno
Mar 20, 2013·Current Heart Failure Reports·Konstantinos Drosatos, P Christian Schulze
Dec 24, 2013·Journal of Biomedical Science·Jing-Yi ChenHsiu-Chuan Chou
Sep 16, 2014·Molecular Medicine·Ashbeel RoyMarco A M Prado
Sep 28, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Seung-Ah LeeWilliam S Blaner
May 11, 2015·Journal of Ethnopharmacology·Lerato Seleteng KoseSandy Van Vuuren
Oct 23, 2015·Oxidative Medicine and Cellular Longevity·Paweorn AngsutararuxSurapol Issaragrisil
Jan 7, 2017·Circulation Research·Geoffrey Burnstock
Apr 11, 2017·Cardiovascular Research·Julia Ritterhoff, Rong Tian
May 16, 2018·Nucleic Acids Research·Jasmine ChongJianguo Xia
Jan 24, 2019·Journal of Traditional and Complementary Medicine·Mohammad Yaseen Khan, Vimal Kumar

❮ Previous
Next ❯

Software Mentioned

Agilent Chemstation
Excel Spreadsheet
Statistical Package for the Social Sciences ( SPSS )
MetaboAnalyst

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.