Turn-specific and pigment-dependent differences in the stria vascularis of normal and gentamicin-treated albino and pigmented guinea pigs

Hearing Research
J W ConleeD J Creel

Abstract

The aims of the present study were to determine which structures in the stria vascularis (SV) may depend upon the presence of pigmented melanocytes both for normal morphology and for the expression of gentamicin ototoxicity in the inner ear. These pigment-dependent influences were inferred through comparisons of the SV in pigmented guinea pigs and in albinos containing nonpigmented melanocytes. Results were obtained from 6 albino and 8 pigmented guinea pigs given gentamicin, and from 3 albino and 3 pigmented control animals not receiving the drug. One-month old animals received gentamicin daily (100 mg/kg) for 14 days and recovered for an additional 14 days before being prepared for electron microscopy. The SV from each of the 4 cochlear turns was analyzed using stereological point counting procedures. In control animals, differences were found in the higher cochlear turns, where volume density for the marginal cells in albinos was abnormally large (turns 3 and 4), while the volume density for intermediate cells (melanocytes) was abnormally small (turn 3). Cell volume estimates for the intermediate cells were significantly smaller in the albino than pigmented control animals in the higher cochlear turns, indicating that functio...Continue Reading

References

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Citations

Jul 1, 1977·Acta Oto-laryngologica·D A Hilding, R D Ginzberg
Apr 1, 1976·The Journal of the Acoustical Society of America·J Schacht
Jan 1, 1979·Archives of Oto-rhino-laryngology·J Schacht
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Related Concepts

Albinism
Melanocyte
Gentavet
Gentamicins
Cavia
Gentacycol
Science of Morphology
Electron Microscopy, Diagnostic
Electron Microscopy
Gentamicin Measurement

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