PMID: 6161227Sep 1, 1980Paper

Turnaround of axoplasmic transport of selected particle-specific enzymes at an injury in control and diisopropylphosphorofluoridate-treated rats

Journal of Neurochemistry
R E SchmidtD B McDougal

Abstract

Reversal of direction (turnaround) of axonal transport of particle-specific enzyme activities was studied at a ligature placed on rat sciatic nerve. In the principal experiment, the ligature remained on the nerve in vivo several hours, allowing enzyme activities (acetylcholinesterase, acid phosphatase, and monoamine oxidase) to accumulate immediately proximal to the tie. The nerve was then tied a second time, proximal to the first tie, and incubated in vitro for several more hours. Accumulation of enzyme activities just distal to the second tie was measured. This second accumulation, of activities traveling in the retrograde direction, was shown to be the result of turnaround in several ways. (1) The increase in activity distal to the second tie was equal to the decrease in activity proximal to the first. (2) The increase in enzyme activities distal to the second tie was greatly reduced when the accumulation proximal to the first tie was trapped by placing a third tie between the first and second ties. (3) It was shown that the activity that accumulated distal to the second tie could not have been in retrograde motion at the time of the first tie. (4) Accumulation distal to the second tie was not a function of the length of ner...Continue Reading

References

Aug 1, 1977·Journal of Neurochemistry·M A Bisby, V T Bulger
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Citations

Sep 1, 1993·The European Journal of Neuroscience·R S Smith, M A Bisby
Apr 1, 1982·Journal of Neurochemistry·D V SinicropiD L McIlwain
Feb 1, 1985·Journal of Neurochemistry·C D Carrington, M B Abou-Donia
Dec 1, 1991·Journal of Neurochemistry·R HässigL Di Giamberardino

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