Turner syndrome and genetic polymorphism: a systematic review

Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo
Alessandra Bernadete Trovó de Marqui

Abstract

To present the main results of the literature on genetic polymorphisms in Turner Syndrome and their association with the clinical signs and the etiology of this chromosomal disorder. The review was conducted in the PubMed database without any time limit, using the terms Turner syndrome and genetic polymorphism. A total of 116 articles were found, and based on the established inclusion and exclusion criteria 17 were selected for the review. The polymorphisms investigated in patients with Turner Syndrome were associated with growth deficit, causing short stature, low bone mineral density, autoimmunity and cardiac abnormalities, which are frequently found in patients with Turner Syndrome. The role of single nucleotide polymorphisms (SNPs) in the etiology of Turner syndrome, i.e., in chromosomal nondisjunction, was also confirmed. Genetic polymorphisms appear to be associated with Turner Syndrome. However, in view of the small number of published studies and their contradictory findings, further studies in different populations are needed in order to clarify the role of genetic variants in the clinical signs and etiology of the Turner Syndrome.

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Citations

Jun 20, 2017·International Journal of Immunogenetics·E Villanueva-OrtegaG Queipo
Aug 19, 2017·Biology of Sex Differences·Rachael J WernerNora Engel
Mar 20, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rehotbevely Barrientos-RiosLeda Torres

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BETA
hormone replacement therapy
dissection

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