Turner's syndrome in fetal life

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
E SurerusL D Allan

Abstract

To compare the incidence and type of heart disease found in association with 45X karyotype in fetal life with postnatal life and to examine the outcome after fetal diagnosis. Fifty-three fetuses with a 45X karyotype were examined echocardiographically over a 4-year period between 1999 and 2002. Of these, 47 were referred because of increased nuchal translucency (NT). A cardiac abnormality was detected in 33/53 (62.2%) fetuses. The most common diagnosis was coarctation of the aorta in 24/53 (45.3%) fetuses, followed by the hypoplastic left heart syndrome (HLHS) in 7/53 (13.2%) fetuses. The mean NT was significantly higher in fetuses with a heart defect than in those with normal echocardiography. Termination of pregnancy was carried out in 45/53 (84.9%) fetuses and intrauterine death occurred in six cases. Two of four fetuses with a mosaic karyotype are currently alive. Turner's syndrome is associated with a higher incidence of heart defects detected prenatally when compared to postnatal reports. The commonest associated heart defects detected prenatally are HLHS and coarctation of the aorta, in contrast to postnatal life where a bicuspid aortic valve is the most common diagnosis. The typical intrauterine presentation of Turner's...Continue Reading

References

Jan 1, 1992·Fetal Diagnosis and Therapy·K H NicolaidesC M Gosden
Sep 1, 1991·The British Journal of Radiology·A M MacLeod, J M McHugo
Jul 1, 1988·British Heart Journal·H van EgmondA Devloo-Blancquaert
Jan 1, 1983·The Journal of Pediatrics·M J MillerW F Friedman
Nov 1, 1994·Archives of Disease in Childhood·C O GøtzscheB O Kristensen
May 1, 1993·The British Journal of Radiology·P Twining, J Zuccollo
Jan 6, 1996·BMJ : British Medical Journal·C H GravholtJ Hansen
Dec 5, 1996·The New England Journal of Medicine·P Saenger
Feb 26, 1998·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·U GembruchM Hansmann
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·K Landin-WilhelmsenL Wilhelmsen
Jul 9, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M C HaakJ M G Van Vugt

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Citations

Oct 8, 2008·Current Opinion in Cardiology·Carolyn A Bondy
Jan 27, 2007·Journal of Cardiovascular Medicine·Gerardo PiacentiniBruno Marino
Apr 6, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Narayan P IyerJean W Matthes
Sep 9, 2015·Cardiology in the Young·Benjamin J LandisRobert B Hinton
Mar 28, 2006·Prenatal Diagnosis·Israel Goldstein, Arie Drugan
Jul 17, 2010·American Journal of Medical Genetics. Part a·Laura BernardiniBruno Dallapiccola
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Wanda C Miller-Hance, Theresa A Tacy
Apr 10, 2012·Early Human Development·Ritu MograJon Hyett
May 10, 2008·Journal of the American College of Cardiology·Vandana SachdevCarolyn A Bondy
Jan 4, 2012·Journal of the American College of Cardiology·Jeffrey A FeinsteinGerard R Martin
Oct 14, 2008·Archives of Cardiovascular Diseases·Yves DulacPhilippe Acar
Apr 13, 2004·Current Opinion in Cardiology·Aarti Hejmadi Bhat, David J Sahn
Aug 6, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marcin WiechecInga Ludwin
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Fatema Nassar, Emily DeFranco
May 12, 2016·Revista da Associação Médica Brasileira·Vanessa Vigna GoulartMarcelo Zugaib
Jul 31, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Y SanhalG Luleci
May 1, 2004·Circulation Research·Jesse ChristiansenMartin J Somerville
Sep 19, 2007·Circulation·Lea Ann MaturaCarolyn A Bondy
Oct 3, 2013·Circulation. Cardiovascular Imaging·Laura J OlivieriCarolyn A Bondy
Apr 26, 2014·Circulation·Mary T DonofrioUNKNOWN American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in
Feb 4, 2014·Clinical Obstetrics and Gynecology·Anita J Moon-Grady, Suguna Ganesan
Jun 19, 2012·Endocrine Reviews·Kristian H MortensenClaus H Gravholt
Jul 15, 2017·European Journal of Endocrinology·Claus H GravholtUNKNOWN International Turner Syndrome Consensus Group

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