DOI: 10.1101/459271Nov 1, 2018Paper

Turning and twisting motion of chromosomes as an accelerating force to align homologous chromosomes during meiosis

BioRxiv : the Preprint Server for Biology
Kazutaka TakaoAkinori Awazu


Homologous sets of parental chromosomes must pair during meiosis to produce recombined sets of chromosomes for their progeny. This is accompanied by nuclear oscillatory movements. This study aimed to elucidate the significance of these movements with a model, wherein external force was applied to the oscillating nucleus and via hydrodynamic interactions within the nucleus. Simulations revealed that a major force for aligning homologous chromosomes is length-dependent sorting during chromosomal turning and twisting, which occur when the nucleus reverses the direction of its movement.

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