Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells

Journal of Cellular Biochemistry
Melissa B RogersNadia N Shaikh

Abstract

The concentration, location, and timing of bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) gene expression must be precisely regulated. Abnormal BMP2 levels cause congenital anomalies and diseases involving the mesenchymal cells that differentiate into muscle, fat, cartilage, and bone. The molecules and conditions that influence BMP2 synthesis are diverse. Understandably, complex mechanisms control Bmp2 gene expression. This review includes a compilation of agents and conditions that can induce Bmp2. The currently known trans-regulatory factors and cis-regulatory elements that modulate Bmp2 expression are summarized and discussed. Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell behavior. In mesenchymal cells, the concentration of BMP2 influences myogenesis, adipogenesis, chondrogenesis, and osteogenesis. Because the amount, timing, and location of BMP2 synthesis influence the allocation of cells to muscle, fat, cartilage, and bone, the mechanisms that regulate the Bmp2 gene are crucial. Key early mesodermal events that require precise Bmp2 regulation include heart specification and morphogenesis. Original...Continue Reading

References

Apr 1, 1993·The Journal of Clinical Investigation·K BoströmL L Demer
Nov 13, 1999·Nature Cell Biology·J Rodriguez-LeonJ M Hurle
Aug 4, 2001·Biochemical and Biophysical Research Communications·N Ghosh-ChoudhuryS E Harris
Jan 22, 2003·Biochemical and Biophysical Research Communications·Gerard BainJackie Papkoff
Mar 5, 2003·Journal of Cellular Biochemistry·Louis C GerstenfeldThomas A Einhorn
Jun 5, 2003·The Journal of Clinical Investigation·I R GarrettG R Mundy
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Naoshi FukuiLinda J Sandell
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Georges RawadiSergio Roman-Roman
Feb 6, 2004·The Journal of Biological Chemistry·Kevin L AbramsMelissa B Rogers
Mar 30, 2004·Biomaterials·Gun-Il ImArun S Shanbhag
Sep 11, 2004·The Journal of Biological Chemistry·David T FritzMelissa B Rogers
Jan 14, 2005·Nucleic Acids Research·Bin TianCarol S Lutz
May 13, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Satish GhatpandeTodd Evans
Mar 31, 2009·American Journal of Human Genetics·Katarina DatheStefan Mundlos
Jan 12, 2010·Biochemical and Biophysical Research Communications·Shan JiangMelissa B Rogers
May 1, 2010·Journal of Cellular Biochemistry·Shan JiangMelissa B Rogers
Jan 27, 2011·Journal of Cellular Biochemistry·Boudewijn P T KruithofMelissa B Rogers
Apr 20, 2011·Genesis : the Journal of Genetics and Development·Boudewijn P T KruithofMelissa B Rogers
Jul 28, 2011·Journal of Cellular Biochemistry·Grace L Lin, Kurt D Hankenson
Feb 22, 2012·Developmental Cell·José Luis de la Pompa, Jonathan A Epstein

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Citations

Apr 12, 2016·Current Opinion in Biotechnology·Maureen R Newman, Danielle Sw Benoit
Apr 13, 2017·Genesis : the Journal of Genetics and Development·Tapan A ShahMelissa B Rogers
Nov 16, 2017·International Journal of Molecular Sciences·Yi-Hsiung LinChau-Zen Wang
Apr 7, 2018·Acta Histochemica Et Cytochemica·Tomohiro TakenawaJunichiro Iida
Jul 22, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Nathan F DentonKatherine E Pinnick
Jul 28, 2015·Journal of Cellular Biochemistry·Anastasios FotinosMelissa B Rogers
Feb 22, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michelle Lampl, Meriah Schoen
Jun 22, 2019·FASEB BioAdvances·Vinayak KhattarSelvarangan Ponnazhagan
Aug 5, 2019·Journal of Ethnopharmacology·Victor Gustavo Balera BritoSandra Helena Penha Oliveira
Aug 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Xuming YangShan Xing

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