Mar 18, 2015

Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells

Journal of Cellular Biochemistry
Melissa B RogersNadia N Shaikh

Abstract

The concentration, location, and timing of bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) gene expression must be precisely regulated. Abnormal BMP2 levels cause congenital anomalies and diseases involving the mesenchymal cells that differentiate into muscle, fat, cartilage, and bone. The molecules and conditions that influence BMP2 synthesis are diverse. Understandably, complex mechanisms control Bmp2 gene expression. This review includes a compilation of agents and conditions that can induce Bmp2. The currently known trans-regulatory factors and cis-regulatory elements that modulate Bmp2 expression are summarized and discussed. Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell behavior. In mesenchymal cells, the concentration of BMP2 influences myogenesis, adipogenesis, chondrogenesis, and osteogenesis. Because the amount, timing, and location of BMP2 synthesis influence the allocation of cells to muscle, fat, cartilage, and bone, the mechanisms that regulate the Bmp2 gene are crucial. Key early mesodermal events that require precise Bmp2 regulation include heart specification and morphogenesis. Original...Continue Reading

Mentioned in this Paper

Calcinosis
Degenerative Polyarthritis
Myogenesis
Regulation of Biological Process
Congenital Neurologic Anomalies
BMP2 gene
Chondrogenesis
BMP2
Gene Expression
Cell Differentiation Process

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