Turning mesoderm into kidney

Seminars in Cell & Developmental Biology
Alan J DavidsonVeronika Sander

Abstract

The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesoderm forms during gastrulation/axis elongation and how it progressively gives rise to distinct renal progenitors along the rostro-caudal axis. We highlight some of the potential signalling cues and core transcription factor circuits that direct these processes, up to the point of early metanephric kidney formation.

Citations

Mar 14, 2020·Biomolecules·Marietta HerrmannFranz Jakob
Apr 15, 2020·Annals of Biomedical Engineering·Katya D'CostaMilica Radisic
Aug 28, 2021·Genes·Katrina Chan, Xiaogang Li

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