PMID: 9427245Jan 14, 1998Paper

Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC

Neuron
J R de la TorreChristine E Holt

Abstract

Netrin-1 promotes outgrowth of axons in vitro through the receptor Deleted in Colorectal Cancer (DCC) and elicits turning of axons within embryonic explants when presented as a point source. It is not known whether netrin-1 alone can elicit turning nor whether DCC mediates the turning response. We show that Xenopus retinal ganglion cell growth cones orient rapidly toward a pipette ejecting netrin-1, an effect blocked by antibodies to DCC. In vitro, netrin-1 induces a complex growth cone morphology reminiscent of that at the optic nerve head, a site of netrin-1 expression in vivo. These results demonstrate that netrin-1 can function alone to induce turning, implicate DCC in this response, and support the idea that netrin-1 contributes to steering axons out of the retina.

References

Jan 1, 1992·Neuron·R J RivasD J Goldberg
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·M PlaczekT M Jessell
Jan 1, 1985·Journal of Neuroscience Research·W A HarrisN Gallenson
Jan 1, 1985·Journal of Neuroscience Research·R W Gundersen
Apr 1, 1984·Developmental Biology·W Halfter, S Deiss
May 1, 1981·Developmental Biology·S Krayanek, S Goldberg
Jan 1, 1980·The Journal of Comparative Neurology·J Silver, R L Sidman
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Apr 22, 1994·Cell·A Hemmati-Brivanlou, D A Melton
Oct 1, 1995·Molecular and Cellular Neurosciences·P A Brittis, J Silver
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Apr 24, 1997·Nature·E D LeonardoM Tessier-Lavigne
Mar 1, 1997·Mechanisms of Development·U SträhleP Blader
Jan 1, 1997·Molecular and Cellular Neurosciences·J D LauderdaleJ Y Kuwada

❮ Previous
Next ❯

Citations

Oct 8, 1999·Journal of Neurobiology·G J Goodhill, J S Urbach
Aug 2, 2002·Journal of Neurobiology·Shane C D Ferguson, Sarah McFarlane
Oct 17, 2002·Journal of Neurobiology·Andreas WalzChristine E Holt
Sep 29, 2004·Journal of Neurobiology·Derek N AdamsPaul C Letourneau
Oct 22, 2003·Developmental Biology·C A WebberS McFarlane
Sep 15, 2001·Brain Research. Developmental Brain Research·K JohanssonB Ehinger
Jul 20, 2002·Trends in Neurosciences·William G Wadsworth
Jun 1, 2000·Progress in Neurobiology·C A Stuermer, M Bastmeyer
Jan 24, 2002·Mechanisms of Development·Toshiaki NakashibaShigeyoshi Itohara
Nov 18, 1998·Current Opinion in Cell Biology·J G Culotti, D C Merz
May 6, 1998·Current Opinion in Neurobiology·G CookR Keynes
Nov 13, 2001·Developmental Cell·F V MarianiR M Harland
Nov 4, 2005·Nature·Isabelle BrunetChristine Holt
Jun 10, 2008·Nature Neuroscience·Makoto NishiyamaKyonsoo Hong
Sep 12, 2006·Nature Neuroscience·Karen Y WuSamie R Jaffrey
Sep 19, 2006·Nature Neuroscience·Kin-Mei LeungChristine E Holt
Mar 16, 2007·Nature Reviews. Molecular Cell Biology·Vincenzo Cirulli, Mayra Yebra
Oct 20, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Nirveek BhattacharjeeAlbert Folch
Aug 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Phillip A NewmarkAlejandro Sánchez Alvarado
Apr 20, 2012·Stem Cells and Development·Gerhard W HillRobert Keith Duncan
Jul 11, 2009·Science·Simon W MooreMichael P Sheetz
Dec 5, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S McFarlane
Dec 5, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T E Kennedy
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Michael Piper, Christine Holt
Apr 15, 1999·Annual Review of Neuroscience·B K Mueller
Oct 13, 2004·Neural Computation·Geoffrey J GoodhillJeffrey S Urbach
Dec 14, 2007·Development·Laure StrochlicChristine E Holt
Nov 24, 2004·The International Journal of Developmental Biology·Fanny MannChristine E Holt
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristy Welshhans, Gary J Bassell
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colleen ManittSusana Cohen-Cory
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon W MooreMichael P Sheetz
Jan 12, 2002·Biochemical and Biophysical Research Communications·Kit WongMing-Liang He
Jul 6, 2014·Mediators of Inflammation·Punithavathi RanganathanGanesan Ramesh
Jun 18, 2014·The Journal of Clinical Investigation·Isabelle BrunetAnne Eichmann
Sep 13, 2005·Molecular and Cellular Neurosciences·Michael E WardYi Rao
May 6, 2010·American Journal on Intellectual and Developmental Disabilities·Mohammed Rachidi, Carmela Lopes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.