PMID: 6170734Nov 1, 1981Paper

Turnover of axonally transported phospholipids in nerve endings of retinal ganglion cells

Journal of Neurochemistry
A D Toews, P Morell

Abstract

We have investigated the metabolic turnover of axonally transported phospholipids in myelinated axons (optic tract) and nerve endings (superior colliculus) of retinal ganglion cells. One week following intraocular injection of [2-3H]glycerol, turnover rates for individual phospholipid classes in the retina (which contains a number of other cell types in addition to the ganglion cells) were all very similar to each other, with apparent half-lives of approximately 7 days. Apparent half-lives of labeled phospholipids in superior colliculus (presumably primarily in retinal ganglion cell nerve endings) were 10 days for both choline and inositol phosphoglycerides and 13 days for both serine and diacylethanolamine phosphoglycerides. Subcellular fractionation data obtained from superior colliculus at various times after injection suggested that apparent turnover rates determined for nerve ending phospholipids probably were not significantly affected by transfer of axonally transported 3H lipids into myelin. Apparent half-lives for phospholipids in optic tract were somewhat longer than in superior colliculus, ranging from 11 to 18 days. The slower turnover rates in optic tract may, in part, reflect the transfer of some axonal lipids to ...Continue Reading

References

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Citations

Jun 19, 2002·Biochimica Et Biophysica Acta·Beatriz L Caputto, Mario E Guido
Apr 1, 1987·Neurochemical Research·T KunishitaR W Ledeen
Dec 1, 1990·Journal of Neurochemistry·M E Guido, B L Caputto
Jan 27, 2007·Journal of Neurochemistry·Jianfeng WangRobert W Ledeen
Jan 1, 1987·Journal of Neurochemistry·T KunishitaR W Ledeen
Dec 1, 1982·Journal of Neurochemistry·R M GouldN A Ingoglia
Nov 19, 2003·Journal of Neurochemistry·Krishna MenonSteven E Pfeiffer
Nov 1, 1989·Journal of Neuroscience Research·K K Vaswani, R W Ledeen
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Jan 1, 1987·Journal of Neuroscience Research·K K Vaswani, R W Ledeen

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