Turnover of cholesterol and dipalmitoyl phosphatidylcholine in surfactant of adult rat lung

Lipids
M E JonesT E Nicholas

Abstract

In order to compare the turnover of two major surfactant components, [1 alpha,2 alpha (n)-3H]cholesterol and [methyl14C choline] dipalmitoyl phosphatidylcholine (DPPC) were introduced as lamellar bodies via the trachea into lightly anesthetized rats which were then allowed to recover. The radiotracers were assumed to have entered the alveolar surfactant pool and to have subsequently recycled in part into the lamellar bodies of alveolar type II cells. For DPPC, the specific activity vs. time curves of tubular myelin rich (alv-1) and tubular myelin poor (alv-2) alveolar lavage fractions were similar, and there was a plausible precursor-product relationship between lamellar bodies and either (or both) of these compartments. In contrast, however, the specific activities of alv-1 and alv-2 for cholesterol were quite different, allowing us to reject the hypothesis of a precursor-product relationship between classical lamellar bodies and alv-2. The estimated turnover time for DPPC in alv-1 was 240 or 206 min, depending on which subfraction of lamellar bodies one takes to be the precursor. For cholesterol it was 583 or 624 min. These longer turnover times for cholesterol should lead to a greater than twofold increase in the relative co...Continue Reading

References

Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·T E NicholasH A Barr
Nov 1, 1987·International Journal of Bio-medical Computing·M E JonesT E Nicholas
Nov 1, 1986·International Journal of Bio-medical Computing·M E JonesH A Barr
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Jun 1, 1972·The American Journal of Physiology·S L Young, D F Tierney
Jul 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T E Nicholas, H A Barr
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M E Jones, T E Nicholas
Mar 1, 1981·Meditsinskaia tekhnika·Iu A Shvedov, V N Frosin

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Citations

Apr 8, 1999·Progress in Lipid Research·J J Batenburg, H P Haagsman
Jun 1, 1997·Trends in Microbiology·D H Meyer, P M Fives-Taylor
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S Orgeig, C B Daniels
Dec 1, 1996·Respirology : Official Journal of the Asian Pacific Society of Respirology·T E Nicholas
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·I R DoyleJ Pfitzner
Mar 14, 2007·Respiratory Physiology & Neurobiology·Kaushik NagMauricia Fritzen Garcia
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·K G DavidsonI R Doyle

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