Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build

The Journal of Clinical Investigation
P J Nestel, E A Monger

Abstract

The turnover rate of plasma total esterified cholesterol was measured after the intravenous injection of tritiated mevalonic acid in 16 men with coronary heart disease. Four subjects were normocholesterolemic and 12 were hypercholesterolemic; among the latter, 3 suffered from familial hypercholesterolemia and 6 were overweight. The turnover rate of plasma esterified cholesterol was highest among the overweight hypercholesterolemic subjects and least among the subjects with familial hypercholesterolemia. Hypercholesterolemic subjects of normal weight had turnover rates similar to those found in normocholesterolemic men. Significant correlations were found between body surface or body weight and the turnover rate of plasma esterified cholesterol. We conclude that the factors which determine the development of hypercholesterolemia are not identical in all hypercholesterolemic subjects and that when hypercholesterolemia is associated with overweight there is an increased formation of at least plasma esterified cholesterol.

References

Jul 1, 1966·The Journal of Clinical Investigation·P J Nestel, E A Couzens
Jan 1, 1957·The Journal of Clinical Investigation·J T ANDERSONA LAWLER
Nov 1, 1960·The American Journal of Medicine·D B ZILVERSMIT
Jan 1, 1960·Science·C B THOMAS, S M GARN
Sep 1, 1962·The Journal of Clinical Investigation·A V CHOBANIANW HOLLANDER
Sep 1, 1962·The Journal of Clinical Investigation·A V CHOBANIAN, W HOLLANDER
Nov 1, 1964·The Journal of Clinical Investigation·D S GOODMAN
Jun 1, 1965·Annals of Internal Medicine·F H EPSTEINT FRANCIS
Jun 1, 1965·The Journal of Clinical Investigation·P J NESTELE A COUZENS
Nov 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·S LINDSTEDT, E H AHRENS

❮ Previous
Next ❯

Citations

Feb 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·R Goren, L A Simons
Mar 1, 1996·Atherosclerosis·P J Barter, K A Rye
Mar 13, 2002·Atherosclerosis·Dmitri Sviridov, Paul Nestel
Mar 16, 1972·The New England Journal of Medicine·P Clifton-BlighH M Whyte
Mar 1, 1973·European Journal of Clinical Investigation·Y AkanumaN Kuzuya
Feb 1, 1974·Australian Paediatric Journal·J M CourtR F Leonard
Jul 1, 1968·The Journal of Clinical Investigation·I F McKenzie, P J Nestel
May 1, 1969·The Journal of Clinical Investigation·R A Cooper, J H Jandl
Jun 1, 1969·The Journal of Clinical Investigation·P J NestelD S Goodman
Aug 1, 1972·The Journal of Clinical Investigation·A K BhattacharyyaA A Spector
Oct 1, 1975·The Journal of Clinical Investigation·L J Bennion, S M Grundy
Jul 1, 1982·The Journal of Clinical Investigation·C C SchwartzL Swell
Feb 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·K T Stokke, K R Norum
May 1, 1974·Metabolism: Clinical and Experimental·P Clifton-BlighP J Nestel
Jan 1, 1969·Metabolism: Clinical and Experimental·I M Jackson
Apr 1, 1971·Metabolism: Clinical and Experimental·H S SodhiC H Weder
Jul 1, 1976·Clinics in Endocrinology and Metabolism·P Nestel, B Goldrick
Jul 30, 1976·European Journal of Clinical Investigation·B J Kudchodkar, H S Sodhi
Feb 4, 2003·Journal of Lipid Research·Dmitri SviridovPaul Nestel
Nov 1, 1971·Circulation·T A Miettinen
Jan 1, 1974·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K OetteI Kupfer
Sep 1, 1968·Acta Medica Scandinavica·T A Miettinen, I M Penttilä
Mar 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y A Kesaniemi, S M Grundy
May 8, 2018·Journal of Clinical Lipidology·Baiba K GillardHenry J Pownall
Apr 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·B J Kudchodkar, H S Sodhi
Oct 1, 1976·Journal of the Neurological Sciences·J K YaoP J Dyck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Investigation
P J Nestel, E A Couzens
Archives of Disease in Childhood
J M CourtR F Leonard
The New England Journal of Medicine
D S Fredrickson
© 2021 Meta ULC. All rights reserved