Turnover of platelets adhered to fibrinogen-coated surfaces

Thrombosis Research
H M Wang, C J Jen

Abstract

The dynamic interactions between platelets and fibrinogen-coated surfaces were investigated by using a tube-flow device and a rotating rod device. The net platelet accumulation to the fibrinogen-coated surfaces in both devices reached maximal values of 30-40 platelets/1000 um2. This adhesion phenomenon was completely inhibited by EDTA. In the tube-flow device, the density of platelets adhered to the tube surface increased with flow time and decreased with distance from the tube inlet. These adhered platelets were difficult to be washed off the tube surface and showed little turnover. The platelet accumulation kinetics in a rotating rod device increased with rotation speed from 300 rpm to 1200 rpm. At 1200 rpm, about half of these platelets adhered to the rod were exchangeable with platelets in the suspension whereas the rest of them were permanent. The detachment of platelets from the rod surface depended on the presence of erythrocytes and platelets in the suspension and it was facilitated by the presence of EDTA in the suspension. These observations suggest that the turnover of platelets adhered to fibrinogen-coated surfaces depends on experimental conditions.

References

Jan 1, 1979·Transactions - American Society for Artificial Internal Organs·P D RichardsonR Kane
Feb 1, 1986·Journal of Biomechanical Engineering·I A Feuerstein, J Kush
Feb 1, 1972·British Journal of Haematology·J F MustardM A Packham
Jun 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Zucker, L Vroman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.