PMID: 6539062Jun 1, 1984Paper

Turnover of very low-density lipoprotein-apoprotein B is increased by substitution of soybean protein for meat and dairy protein in the diets of hypercholesterolemic men

The American Journal of Clinical Nutrition
M W HuffB M Wolfe

Abstract

The effect of dietary protein source on the kinetics of plasma very low-density lipoprotein (VLDL) (Sf 60 to 400) in hypercholesterolemic men was investigated. Using a crossover design, five subjects received sequentially either 1) a high polyunsaturated fat, low cholesterol control diet containing mixed protein from meat, dairy products, and plant sources or 2) an all-plant protein experimental diet in which the meat and dairy protein of the former diet was replaced by soybean protein and soy milk. There was no significant change in the mean values for fasting serum cholesterol and triglycerides over the 6-wk period of administration of the control versus experimental diets. The kinetics of VLDL (Sf 60 to 400) apolipoprotein B were studied at the end of each dietary period after reinjection of 125I-labeled autologous VLDL (Sf 60 to 400). The VLDL apolipoprotein B pool size was similar during the experimental and control protocols; however, the fractional catabolic rate was consistently higher during the experimental protocol (8.5 +/- 1.3 versus 6.5 +/- 1.2 day-1, p less than 0.01) and the production rate of apoprotein B was higher than control in four of five subjects (mean values 18.6 +/- 3 versus 12.6 +/- 1 mg/day/kg, respec...Continue Reading

Citations

Oct 15, 2010·The Journal of Nutrition·David J A JenkinsPenny M Kris-Etherton
Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Dec 22, 2017·Journal of the American Heart Association·Siying S LiJohn L Sievenpiper
Feb 15, 1988·Klinische Wochenschrift·C A Barth, M Pfeuffer
Nov 15, 1996·The Journal of Biological Chemistry·K CianfloneA D Sniderman
Jan 1, 1991·Nutrition Research Reviews·S M Kingman
Sep 9, 1999·The American Journal of Clinical Nutrition·J W AndersonC S Washnock

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