PMID: 7335150Oct 1, 1981Paper

Turnover rate of molecular species of sphingomyelin in rat brain

Neurochemical Research
F N LeBaronF B Jungalwala

Abstract

Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of benzoylated sphingomyelin were separated and quantitated by reversed-phase high performance liquid chromatography. All individual major molecular species of microsomal and myelin sphingomyelin had maximum incorporation at 6 and 15 days, respectively, after the injection. The specific radioactivity of all the various molecular species of both myelin and microsomal sphingomyelin declined at a similar rate after reaching a maximum. There was no significant difference in the turnover rate of short chain (16:0, 18:0) and long chain (greater than 22:0) fatty acid containing sphingomyelin. The average apparent turnover rate of myelin and microsomal sphingomyelin molecular species was about 14-16 days for the fast pool and about 45 days for the slow pool. It is concluded that individual molecular species of sphingomyelin of myelin and microsomal membranes turned over at a similar rate. Thus, turnover rate of sphingomyelin...Continue Reading

References

Jan 1, 1979·The International Journal of Neuroscience·H Singh, F B Jungalwala
Jan 1, 1976·Advances in Experimental Medicine and Biology·L A HorrocksJ Y Chin
May 1, 1975·Quarterly Reviews of Biophysics·D Chapman
Sep 1, 1973·Journal of Neurochemistry·J M PasquiniE F Soto
Aug 1, 1971·The Biochemical Journal·F B Jungalwala, R M Dawson
Mar 1, 1966·The Biochemical Journal·A N Davison, N A Gregson
Feb 1, 1980·Journal of Neurochemistry·L Freysz, P Mandel

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Citations

Nov 21, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·N U OlssonS Dzeletović
Nov 1, 1983·Journal of Neurochemistry·M Butler, P Morell
Oct 5, 2010·Biochimica Et Biophysica Acta·Veronique E MironJack P Antel
Jan 1, 2013·Brain Sciences·Maria PodbielskaEdward L Hogan
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Apr 24, 2010·The American Journal of Pathology·Veronique E MironJack P Antel

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