Tutorial on Biostatistics: Statistical Analysis for Correlated Binary Eye Data

Ophthalmic Epidemiology
Gui-Shuang YingBernard Rosner

Abstract

To describe and demonstrate methods for analyzing correlated binary eye data. We describe non-model based (McNemar's test, Cochran-Mantel-Haenszel test) and model-based methods (generalized linear mixed effects model, marginal model) for analyses involving both eyes. These methods were applied to: (1) CAPT (Complications of Age-related Macular Degeneration Prevention Trial) where one eye was treated and the other observed (paired design); (2) ETROP (Early Treatment for Retinopathy of Prematurity) where bilaterally affected infants had one eye treated conventionally and the other treated early and unilaterally affected infants had treatment assigned randomly; and (3) AREDS (Age-Related Eye Disease Study) where treatment was systemic and outcome was eye-specific (both eyes in the same treatment group). In the CAPT (n = 80), treatment group (30% vision loss in treated vs. 44% in observed eyes) was not statistically significant (p = 0.07) when inter-eye correlation was ignored, but was significant (p = 0.01) with McNemar's test and the marginal model. Using standard logistic regression for unfavorable vision in ETROP, standard errors and p-values were larger for person-level covariates and were smaller for ocular covariates than us...Continue Reading

References

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Jan 20, 2017·Ophthalmic Epidemiology·Gui-Shuang YingBernard Rosner

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Citations

Feb 15, 2018·The British Journal of Ophthalmology·Harrison G Zhang, Gui-Shuang Ying
Dec 12, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Atay VuralRana Karabudak
Apr 4, 2020·Statistical Methods in Medical Research·Guogen Shan
Apr 4, 2020·Annals of Clinical and Translational Neurology·Martina RomagnoliValerio Carelli
May 12, 2020·Investigative Ophthalmology & Visual Science·Sonja G KarstEduardo V Navajas
Sep 17, 2020·Investigative Ophthalmology & Visual Science·Gui-Shuang YingBernard Rosner
Apr 29, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alba M Garcia-Del ValleDavid P Piñero
Oct 3, 2018·Translational Vision Science & Technology·Masoud Aghsaei FardPrem S Subramanian
Oct 21, 2020·PloS One·Sara RisseeuwJeannette Ossewaarde-van Norel
Nov 29, 2020·European Journal of Ophthalmology·Merve Beyza YildizYılmaz Çetinkaya
May 6, 2021·American Journal of Ophthalmology·Francisco Arnalich-MontielDavid Mingo-Botín
Feb 18, 2021·Journal of Glaucoma·Sebastião Cronemberger, Artur W Veloso
Jul 27, 2021·Investigative Ophthalmology & Visual Science·Joseph JulianoGrace M Richter
Jul 30, 2021·Investigative Ophthalmology & Visual Science·Wei-Hsuan HuangLing Yeung
Jun 5, 2020·Journal of Imaging·Wenyue ZhuGabriela Czanner
Jul 24, 2021·Annual Review of Vision Science·Maureen G Maguire
Dec 8, 2021·Acta Ophthalmologica·Ana Ortueta-OlartecoecheaPilar Tejada-Palacios

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