TV 3326 for Alzheimer's dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer's-like neuropathology.

The Journal of Pharmacy and Pharmacology
Md Sahab UddinGhulam Md Ashraf

Abstract

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders and a well-recognized cause of dementia with ageing. In this review, we have represented the ChE and MAO inhibitory potential of TV 3326 against AD based on current scientific evidence. The aetiology of AD is quite complex and not completely understood. However, it has been observed that AD involves the deposition of abnormal amyloid beta (Aβ), along with hyperphosphorylation of tau, oxidative stress, low acetylcholine (ACh) level and biometal dyshomeostasis. Due to the complex nature of AD aetiology, active research is required in the areas of development of multitarget drugs with 2 or more complementary biological functions, as they might represent significant progress in the AD treatment. Interestingly, it has been found that TV 3326 (i.e. ladostigil) is regarded as a novel therapeutic agent since it has the potential to cause inhibition of monoamine oxidase (MAO) A and B, and acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain. Furthermore, it has the capacity to reverse memory impairments, which further suggests the ability of this drug to elevate cholinergic activity in the brain. TV 3326 can avert oxidative-nitrative ...Continue Reading

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Citations

May 21, 2020·Molecular Neurobiology·Md Sahab UddinGhulam Md Ashraf
Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Sahab UddinLotfi Aleya
May 10, 2020·International Journal of Molecular Sciences·Md Tanvir KabirMohamed M Abdel-Daim
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Geum Seok JeongHoon Kim
May 16, 2020·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim
Apr 24, 2020·Current Topics in Medicinal Chemistry·Md Tanvir KabirGhulam Md Ashraf
Aug 21, 2020·Neurotoxicity Research·Md Sahab UddinGhulam Md Ashraf
Aug 23, 2020·International Journal of Molecular Sciences·Md Sahab UddinMohamed M Abdel-Daim
Jun 20, 2020·Neurotoxicity Research·Md Tanvir KabirMohamed M Abdel-Daim
Sep 17, 2020·Molecular Neurobiology·Md Sahab UddinMohamed M Abdel-Daim
Jun 20, 2020·Journal of the Neurological Sciences·Md Sahab UddinGhulam Md Ashraf
Jun 5, 2020·Current Topics in Medicinal Chemistry·Md Sahab UddinGhulam M Ashraf
Jun 20, 2021·Bioorganic & Medicinal Chemistry Letters·Murilo K A YonekawaEdson Dos A Dos Santos
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tjaša MazejMatej Sova
Nov 25, 2020·Current Gene Therapy·Md Sahab UddinGhulam Md Ashraf

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