Abstract
Treatment of latent tuberculosis (TB) infection (LTBI) effectively prevents its progression to active TB. However, long treatment duration and drug-related hepatotoxicity limit the effectiveness of the 9-month daily isoniazid (9H). Data on the 3-month weekly rifapentine plus isoniazid (3 HP) in Asian populations are currently unavailable. We prospectively randomised the LTBI contacts aged ≥12 years with positive tuberculin skin test into 9H and 3 HP groups in four hospitals between January 2014 and May 2016 in Taiwan. The primary and secondary outcomes were treatment completion rate and adverse drug reactions (ADRs), respectively. Overall, 263 participants with LTBI were randomised into the 3 HP (n = 132) and 9H groups (n = 131); 14 (10.6%) and 29 (22.1%) participants in the 3 HP and 9H groups, respectively, discontinued therapy (p = 0.011). Discontinuation rates owing to ADRs were 9.1% (3 HP) and 5.3% (9H) (p = 0.241). Clinically relevant hepatotoxicity was more common in the 9H than in the 3 HP group (5.3% vs. 1.5%; p = 0.103), whereas systemic drug reaction was more common in the 3 HP than in the 9H group (3.8% vs. 0%; p = 0.060). Women had a significantly higher rate of Grade II fever than men (13.7% vs. 1.2%; p = 0.003). C...Continue Reading
Citations
Oct 27, 2018·The European Respiratory Journal·Lei GaoUNKNOWN LATENTTB-NSTM study team
Mar 20, 2019·The European Respiratory Journal·Pei-Chun ChanChen-Yuan Chiang
Jun 9, 2019·Journal of Clinical Medicine·Meng-Rui LeeInn-Wen Chong
May 8, 2020·International Journal of Circumpolar Health·G G AlvarezA Zwerling
Nov 21, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hung-Ling HuangInn-Wen Chong
Dec 29, 2020·Antimicrobial Agents and Chemotherapy·Shu-Yung LinChong-Jen Yu
Dec 12, 2020·Expert Review of Respiratory Medicine·Chandrasekaran PadmapriyadarsiniRanjani Ramachandran
Mar 8, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hung-Ling HuangInn-Wen Chong
Jun 3, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Hsing WuChih-Chao Yang
Sep 11, 2021·Scientific Reports·Edward Chia-Cheng LaiMeng-Yu Weng
Sep 16, 2019·Respiratory Medicine·Chang Suk NohMoon Seong Baek
Sep 1, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hung-Ling HuangJann-Yuan Wang
Nov 9, 2021·Journal of the Chinese Medical Association : JCMA·Shao-Yu TsengYi-Hsiang Huang
Dec 17, 2021·PLoS Medicine·Fred C SemitalaAdithya Cattamanchi