Twelve-nucleotide repeat polymorphism of D4 dopamine receptor gene in Chinese familial schizophrenic patients

Biological Psychiatry
C J HongC B Sim

Abstract

Disturbances in dopaminergic transmission have been implicated in the etiology of schizophrenia. Catalano et al reported an association between delusional disorder and the number of a 12-nucleotide (bp) repeat sequence in the first exon of dopamine D4 receptor gene (DRD4), which indicated a possible role of this polymorphism in the pathogenesis of psychotic disorders. DNA of 42 Chinese controls, 50 sporadic schizophrenic patients, and 30 familial schizophrenic probands were collected. Genotype of the 12-bp repeat polymorphism of DRD4 was determined with polymerase chain reaction and agarose gel electrophoresis. Genotypic and allelic frequencies were compared among the three groups using the chi-square test. Forty-three (86%) sporadic schizophrenic patients, 25 (83.3%) familial schizophrenic probands, and 35 (83.3%) controls were A1 (two 12-bp repeat) homozygotes. One (2.0%) sporadic schizophrenic and 1 familial schizophrenic patient were A2 (one 12-bp repeat) homozygotes. There was no significant difference in allelic and genotypic distributions among the three groups. The present data do not support an association between schizophrenia and any specific allele of the 12-bp repeat polymorphism of DRD4. Significance of familial/s...Continue Reading

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Citations

May 23, 2012·Molecular Neurobiology·Jing WuLing-Qiang Zhu
Jan 3, 2001·European Journal of Pharmacology·A H WongH H Van Tol
Mar 22, 2003·Schizophrenia Research·Erik G JönssonSven Cichon
May 21, 2010·Neurological Research·Paulo Henrique Pires de AguiarLaurence Katznelson
Dec 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nipa BhaduriKanchan Mukhopadhyay
May 7, 2002·American Journal of Medical Genetics·Alessandro SerrettiEnrico Smeraldi

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