Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle

The Journal of Physiology
Robert A JacobsCarsten Lundby

Abstract

The role of hypoxia on skeletal muscle mitochondria is controversial. Studies superimposing exercise training on hypoxic exposure demonstrate an increase in skeletal muscle mitochondrial volume density (Mito(VD)) over equivalent normoxic training. In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported following mountaineering expeditions. These observations may, however, be confounded by negative energy balance, which may obscure the results. Accordingly we sought to examine the effects of high altitude hypoxic exposure on mitochondrial characteristics, with emphasis on Mito(VD), while minimizing changes in energy balance. For this purpose, skeletal muscle biopsies were obtained from nine lowlanders at sea level (Pre) and following 7 and 28 days of exposure to 3454 m. Maximal ergometer power output, whole body weight and composition, leg lean mass and skeletal muscle fibre area all remained unchanged following the altitude exposure. Transmission electron microscopy determined that intermyofibrillar (IMF) Mito(VD) was augmented (P = 0.028) by 11.5 ± 9.2% from Pre (5.05 ± 0.9%) to 28 Days (5.61 ± 0.04%). In contrast, there was no change in subsarcolemmal (SS) Mito(VD). As a result, total Mito(VD) (IM...Continue Reading

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Citations

Mar 2, 2016·The Journal of Physiology·D A GiussaniA L Fowden
Apr 5, 2016·Travel Medicine and Infectious Disease·Gerard FlahertyNiall Johnston
Feb 7, 2017·Medicine and Science in Sports and Exercise·Stefan M PasiakosJohn W Carbone
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Dec 5, 2015·Frontiers in Physiology·Terence E RyanJoseph M McClung
Nov 18, 2018·Frontiers in Physiology·Almaz AkunovAkpay Sarybaev
Apr 2, 2021·Nature·Anthony King

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