Twenty-five years of experience with physiological neurosurgery

Neurosurgery
I S COOPER

Abstract

Twenty-five years of experience with physiological neurosurgery for the treatment of movement disorders leads the author to conclude that such syndromes are caused by disordered mechanisms of sensory communication within the brain. The physiological and therapeutic effects of ablation of the posterior portions of the ventrolateral nucleus of the thalamus, the stimulation of the anterior or rostral cerebellar cortex, and deep brain stimulation of some thalamic nuclei are due to the decrease of pathological disinhibition of motor mechanisms. Further advances in the reversal of chronic neurological symptoms by the alleviation of pathological sensory disinhibition are anticipated.

Citations

Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D Speelman, J van Manen
Aug 15, 2013·The Cerebellum·G GrimaldiU Ziemann
Jan 1, 1988·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·A B JennyR H Knapp
Jun 15, 2013·Neural Plasticity·Nordeyn Oulad Ben Taib, Mario Manto
Dec 16, 2017·The Cerebellum·Maximilian J Wessel, Friedhelm C Hummel
Oct 31, 2002·Nature Neuroscience·John P Donoghue
Jun 6, 2019·The Cerebellum·Lauren N MiterkoRoy V Sillitoe
May 28, 2021·Journal of Neuroengineering and Rehabilitation·Aamir AbbasiTanuj Gulati

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