Twenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients

Journal of Ophthalmology
Chiara PosarelliMichele Figus

Abstract

This study assessed the 24 h circadian rhythm of intraocular pressure (IOP) using a contact lens sensor in three groups of patients with open-angle glaucoma. This study was a monocentric, cross-sectional, nonrandomized, prospective, pilot study. Eighty-nine patients were enrolled: 29 patients previously underwent an Ex-PRESS mini glaucoma device procedure (Group 1), 28 patients previously underwent Hydrus microstent implantation (Group 2), and 32 patients were currently being treated medically for primary open-angle glaucoma (Group 3). Circadian rhythm patterns were considered with five circadian indicators: fluctuation ranges, maximum, minimum, acrophase (time of peak value), and bathyphase (time of trough value). A two-tailed Mann-Whitney U-test was used to evaluate differences between groups. All subjects exhibited a circadian rhythm and a nocturnal pattern. The signal fluctuation range was significantly smaller in the surgical groups than in the medically treated group (Group 1 vs. Group 3, p=0.003; Group 2 vs. Group 3, p=0.010). Subjects who underwent the Ex-PRESS procedure (Group 1) exhibited significant differences compared with the drug therapy group (Group 3) with regard to the minimum value (p=0.015), acrophase (p=0.0...Continue Reading

References

Jun 5, 2003·Journal of Glaucoma·Edward HughesJeremy Diamond
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Mar 17, 2015·Journal of Glaucoma·Gábor HollóPéter Vargha
Jul 15, 2015·Clinical & Experimental Ophthalmology·Kaweh MansouriRobert N Weinreb
Nov 1, 2015·Progress in Brain Research·Marco NardiMichele Figus
Feb 26, 2016·Advances in Therapy·Anastasios G P KonstasStefano Miglior
May 10, 2016·Investigative Ophthalmology & Visual Science·Marek RekasD Robert Iskander
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Feb 27, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ronan ConlonIqbal Ike K Ahmed

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Citations

Jan 6, 2021·International Journal of Molecular Sciences·Vladimir NeroevDenis Gubin
Jan 27, 2021·International Journal of Molecular Sciences·Michal FiedorowiczMario Damiano Toro
May 1, 2021·International Journal of Molecular Sciences·Agnieszka KamińskaMario Damiano Toro
Jan 7, 2022·International Ophthalmology·Carmen GruzeiRupert Bourne

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Software Mentioned

Ex
PRESS
MATLAB
mVEq

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