PMID: 6400712Sep 1, 1983Paper

Twenty-four-hour cortisol profiles demonstrate exaggerated nocturnal rise in diabetic children

Diabetes Care
T G LebingerJ W Finkelstein

Abstract

Plasma cortisol was measured every 20 min for 24 h in 12 normal and 8 insulin-dependent, nonketotic, diabetic children treated with one daily injection of insulin. Plasma glucose was also measured every 20 min in the diabetic children. The diurnal pattern of cortisol secretion was identical. The mean 24-h plasma cortisol was similar in both groups, but significantly elevated in the diabetic children between 0200 and 0920 h. Peak cortisol levels were higher in the diabetic than in the normal children. No correlation was found between average plasma glucose and average plasma cortisol, or between the nocturnal change in plasma glucose and average nocturnal plasma cortisol in the diabetic subjects. These studies demonstrate an exaggeration of the normal nocturnal rise in plasma cortisol in diabetic children not related to the levels of plasma glucose.

Citations

Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·P M Toleikis, D V Godin
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·F Homo-DelarcheM Dardenne
Oct 16, 2002·Journal of Psychosomatic Research·Patrick J Lustman, Ray E Clouse
Oct 1, 1992·Journal of Neuroendocrinology·M F DallmanC S Cascio
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M Magariños, B S McEwen
Jan 1, 1988·Life Sciences·M H OsterJ S Stern
Aug 4, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Parham ReisiReza Lashgari
Feb 1, 1988·Diabetes/metabolism Reviews·M McMahonR Rizza

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.