Twenty-four hour intraocular pressure reduction with latanoprost compared with pilocarpine as third-line therapy in exfoliation glaucoma

Eye
A G KonstasW C Stewart

Abstract

To compare the 24 hour efficacy of latanoprost 0.005% given every evening with that of pilocarpine 4% given four times daily as third-line therapy in patients with exfoliation glaucoma receiving timolol 0.5% and dorzolamide 2% each given twice daily. We enrolled 30 patients with exfoliation glaucoma not adequately controlled on timolol maleate 0.5% and dorzolamide 2%. Each patient underwent a baseline 24 hour intraocular pressure curve testing at 06:00, 10:00, 14:00, 18:00, 22:00 and 02:00 hours. Patients were randomised to receive either latanoprost 0.005% or pilocarpine 4% for a minimum of 8 weeks and were then crossed over to the opposite therapy. Diurnal curve testing was repeated at the end of each treatment. There was a significant decrease from baseline in intraocular pressure at each timepoint for both study medicines (p < 0.016). Latanoprost provided better intraocular pressure control than pilocarpine at daytime measuresments (17.4 vs 19.7 mmHg at 06:00 hours, p < 0.001; 17.8 vs 19.1 mmHg at 10:00 hours, p = 0.04). However, pilocarpine reduced the pressure more than latanoprost at 22:00 hours (18.4 vs 19.5 mmHg, p = 0.016). Overall, the diurnal intraocular pressure was reduced from a baseline of 21.5 +/- 3.7 mmHg to 1...Continue Reading

References

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Citations

Feb 13, 2001·Survey of Ophthalmology·R Ritch, U Schlötzer-Schrehardt
Mar 3, 2004·Optometry : Journal of the American Optometric Association·Joseph Sowka
May 1, 2004·Optometry : Journal of the American Optometric Association·Joseph Sowka
Mar 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·William C StewartJeanette A Stewart
Feb 5, 2005·Ophthalmology·Anastasios G P KonstasWilliam C Stewart
May 31, 2002·American Journal of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Sep 8, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Leonard K SeiboldMalik Y Kahook
May 2, 2013·The Cochrane Database of Systematic Reviews·Heather WatermanRobert Harper
Oct 20, 2019·Survey of Ophthalmology·Kaweh MansouriRobert N Weinreb

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