PMID: 9537611Apr 16, 1998Paper

Twenty-four-hour L-[1-(13)C]tyrosine and L-[3,3-(2)H2]phenylalanine oral tracer studies at generous, intermediate, and low phenylalanine intakes to estimate aromatic amino acid requirements in adults

The American Journal of Clinical Nutrition
A Basile-FilhoV R Young

Abstract

Daily pattern and rates of whole-body tyrosine oxidation and phenylalanine hydroxylation were determined in young adults (15 men, 1 woman) receiving [13C]tyrosine and [(2)H2]phenylalanine via primed, constant oral infusion and [(2)H4]tyrosine by vein (five subjects also received [(2)H3]leucine simultaneously by vein) continuously for 24 h (12 h fast then 12 h fed). Subjects were given a diet supplying 96.6 (n = 5), 35.6 (the proposed requirement; n = 5), and 18.5 mg phenylalanine x kg(-1) x d(-1) (n = 6) based on an otherwise adequate L-amino acid mixture for 6 d before the 24-h tracer study began. [Each diet was low in tyrosine: 6.79 mg x kg(-1) x d(-1).] Our hypothesis was that subjects would be in tyrosine equilibrium, positive balance, or both, at the 96.6- and 35.6-mg intakes and in distinctly negative balance at the 18.5-mg intake. The diurnal pattern in phenylalanine and tyrosine kinetics was dependent on the intake and, presumably, on the adequacy of dietary phenylalanine. Wholebody tyrosine balances, determined from rates of phenylalanine hydroxylation and tyrosine input and oxidation were negative (0.05 < P < 0.1 from zero balance) with the low (18.5 mg) phenylalanine intake [total aromatic amino acid (AAA) intake: 25...Continue Reading

Citations

May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C C MetgesV R Young
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·A H ForslundV R Young
Dec 24, 2010·Pediatric Research·Jean W HsuWilliam C Heird
Nov 28, 2001·The American Journal of Clinical Nutrition·V R Young
Mar 28, 2002·The American Journal of Clinical Nutrition·Sudhir BorgonhaVernon R Young
Jan 10, 2006·The American Journal of Clinical Nutrition·Jean W-C HsuPaul B Pencharz
Oct 22, 2008·The Journal of Nutrition·Raffaella AntonioneGianni Biolo
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·V R Young, S Borgonha
Feb 7, 2001·The American Journal of Clinical Nutrition·F J van SpronsenP G Smit
Mar 11, 2003·Annual Review of Nutrition·Paul B Pencharz, Ronald O Ball
Jun 10, 2006·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Sep 27, 2002·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Oct 12, 1999·The American Journal of Physiology·C C MetgesV R Young
Oct 23, 2002·Journal of Applied Physiology·Ji XuJohn T Schulz
Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Cécile BosDaniel Tomé
Mar 4, 2015·The American Journal of Clinical Nutrition·Felix LiebauOlav Rooyackers
Nov 15, 2020·The Journal of Nutrition·Madeleine A EnnisRajavel Elango
May 22, 2007·The Journal of Nutrition·Paul B PencharzRonald O Ball
Apr 25, 2000·Metabolism: Clinical and Experimental·J M ThorpeP B Pencharz
Sep 29, 2011·Molecular Genetics and Metabolism·A MacDonaldF Feillet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.