Twenty-four hour melatonin pattern in acromegaly: effect of acute octreotide administration

Journal of Endocrinological Investigation
A A SinisiA Bellastella

Abstract

We investigated the melatonin (MT) circadian rhythm before and after somatostatin (octreotide) acute administration in ten subjects (4 M, 6 F. 23-52 yr old) with active acromegaly due to pituitary microadenoma. Blood samples were drawn every 2 hours over a 48-h span; after 24-h basal blood collection, octreotide (Sandostatin, Sandoz) 100 micrograms sc/8 h was administered. As control, 7 healthy adult subjects (3M, 4F; 26-50 yr old) were studied in basal condition over a 24-h span. Plasma MT and GH levels were measured by RIA in each sample, IGF-1 levels were measured by immunoradiometric assay in basal and after octreotide morning samples. The comparisons were made by Mann-U-Withney and Wilcoxon test as appropriate; the existence of a MT circadian rhythm was validated by cosinor analysis; GH and MT values were correlated by Pearson's correlation coefficient. All of 7 control subjects and 2 of 10 acromegalics had significant 24-h MT rhythm. The area under curve (AUC), mesor and amplitude of the MT rhythms in acromegalics were significantly lower than in the controls (p < 0.001, 0.002 and 0.0006, respectively), with an earlier acrophase (median value: 22:14 vs 02:08 h of controls). Basal plasma IGF-1 levels and circadian GH conce...Continue Reading

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Citations

Mar 1, 2012·Cancer Causes & Control : CCC·E S SchernhammerW Y Chen
Feb 9, 2007·Journal of Pineal Research·Michal KarasekAndrzej Lewinski
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·B CapaldoL Saccà
May 4, 2005·Chronobiology International·Katy BorodkinYaron Dagan

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