Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Annemarie WeissenbacherP J Friend

Abstract

Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ use, and improved transplant logistics. Eleven clinically declined kidneys were perfused normothermically, with 6 being from donors after brain death (median cold ischemia time 33 ± 36.9 hours) and 5 being from donors after circulatory death (36.2 ± 38.3 hours). Three kidneys were perfused using Ringer's lactate to replace excreted urine volume, and 8 kidneys were perfused using urine recirculation to maintain perfusate volume without fluid replenishment. In all cases, normothermic perfusion either maintained or slightly improved the histopathologically assessed tubular condition, and there was effective urine production in kidneys from both donors after brain death and donors after circulatory death (2367 ± 1798 mL vs 744.4 ± 198.4 mL, respectively; P = .44). Biomarkers, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were successfully detected and quantified in the perfusate. All kidneys with urine recirculation were readily perfused for 24 hours (n = 8) and exhibited physiological perfusate sodium levels (140.7 ± 1.2 mmol/L), while kidneys without urine recirculatio...Continue Reading

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Citations

Mar 29, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Franka MessnerGerald Brandacher
Apr 14, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Annemarie WeissenbacherCarlo D L Ceresa
May 7, 2020·Transplantation·Jing XuPaulo N Martins
Mar 7, 2020·Frontiers in Immunology·Yuliia YuzefovychConstanca Figueiredo
Apr 21, 2020·Transplantation Direct·Annemarie WeissenbacherPeter J Friend
Nov 28, 2019·Transplantation Direct·Ahmer M HameedHenry C Pleass
Mar 18, 2020·Frontiers in Immunology·Mindaugas KvietkauskasPeter Schemmer
Apr 27, 2019·Frontiers in Immunology·Jesus M Sierra ParragaMartin J Hoogduijn
Mar 27, 2020·Journal of Clinical Medicine·Julie De Beule, Ina Jochmans
Oct 1, 2020·World Journal of Transplantation·Kurtis J SwansonSandesh Parajuli
Oct 7, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Annemarie WeissenbacherBenedikt M Kessler
Sep 9, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tegwen R ElliottSarah A Hosgood
Jan 6, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Patrick P W LukeRabindra N Bhattacharjee
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Nov 5, 2020·International Journal of Molecular Sciences·Sebastien GiraudThierry Hauet
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Apr 1, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Apr 16, 2021·Kidney International·Asel S ArykbaevaJan H N Lindeman
May 14, 2021·Transplantation·Sarah A HosgoodMichael L Nicholson
Dec 11, 2021·Artificial Organs·Sarah BouariRobert C Minnee

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Methods Mentioned

BETA
biopsy
ELISA

Software Mentioned

GraphPad Prism
Nutriflex
STAT

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