Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis

Modern Rheumatology
Yasumori IzumiKatsumi Eguchi

Abstract

Several clinical trials have demonstrated that leukocytapheresis (LCAP) is a safe and effective therapy for patients with refractory rheumatoid arthritis (RA). However, most of those reports were limited to short-term clinical observation. We have treated 11 RA patients with LCAP and observed them for 24 weeks after the final administration. The 11 cases included 3 diabetes patients, 2 patients with interstitial pneumonia, 1 patient with diffuse panbronchiolitis, and 1 patient with old pulmonary tuberculosis. Alternative therapies for all of these patients were considered difficult. Once-a-week LCAP administration was added for 5 weeks to the previous therapeutic regime in all patients, and the treatment efficacy was prospectively qualified. At 4 weeks after the final LCAP therapy, 8 of the 11 patients (73%) had achieved an American College of Rheumatology (ACR) 20% response, and 3 of the 11 (27%) had achieved both ACR 50% and ACR 70% responses. Although the efficacy decreased after the observation periods, an ACR 20% response was maintained in 5 patients (45%) at 24 weeks. Although only a limited number of patients were examined in this study, the results suggested that LCAP therapy will be beneficial to RA patients, including...Continue Reading

References

Jul 1, 1977·Arthritis and Rheumatism·H E PaulusN S MacDonald
Jul 1, 1979·Arthritis and Rheumatism·D J WallaceJ R Klinenberg
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

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Citations

Jan 5, 2012·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Toshihiko Hidaka
Oct 25, 2011·Modern Rheumatology·Yasumori IzumiKiyoshi Migita
Jun 17, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yukinao SakaiKyoichi Mizuno

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