Twenty-four year single-center experience of hepatitis B virus infection in heart transplantation

Transplantation Proceedings
Y C ChenS S Wang

Abstract

Hepatitis B virus (HBV) infection is hyperendemic in Taiwan. We have reported the outcome of (1) recipients with hepatitis B surface antigen (HBsAg)-positive; HBsAg-negative recipients who receive donor hearts from HBsAg-positive donors; and treatment with lamivudine of hepatitis B flare-ups after heart transplantation, using case numbers that range from 100 to 200. From July 1987 to May 2011, all 412 orthotopic heart transplant recipients and donors underwent routine preoperative screening for hepatitis B virus markers and liver function parameters. Lamivudine was prescribed prophylactically for recipients with elevated serum enzyme levels or an HBV DNA virus load before transplantation, or when there was evidence of hepatitis B flare-up after transplantation. Postoperative HBV markers and liver function parameters were collected over a mean follow-up time of 7.8 years. Thirty-four recipients were HBsAg-positive before heart transplantation, and 23 experiencing HBV reactivation upon follow-up requiring lamivudine treatment. Clinical responses were achieved in all of them: 15 were complete and two, slow partial responses. Twenty-six recipients with an HBV naïve status at the time of heart transplantation, and three patients rec...Continue Reading

References

Nov 25, 2004·Transplantation Proceedings·S-S WangY-T Lee
Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sean P PinneyDonna Mancini
Jan 10, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·W Quinton FosterWendy M Book
Feb 22, 2011·Transplantation Proceedings·M SalvadoriE Bertoni

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Citations

Apr 29, 2014·Transplantation Proceedings·C M LeeJ Wei
Oct 16, 2015·Heart Failure Clinics·Rungroj Krittayaphong, Aekarach Ariyachaipanich
Feb 25, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HuprikarD Kumar
Mar 19, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E Durante-MangoniR Zampino
May 29, 2016·Transplantation Proceedings·Y-J WangS-S Wang
Apr 3, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sara BelgaKaren Doucette
Oct 8, 2020·Current Opinion in Organ Transplantation·Kali Zhou, Selena Zhou
Jun 12, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kyle R KreitmanBenedict J Maliakkal

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