Twenty-year review of radiotherapy for vaginal cancer: an institutional experience

Gynecologic Oncology
Jidong LianRobert Pearcey

Abstract

To evaluate clinical outcome, prognostic factors and chronic morbidity with radiotherapy for vaginal cancer treatment. 68 patients with vaginal cancer treated by radical or adjuvant radiotherapy (RT) were selected. Five with rare subtypes of histopathology and 8 with adenocarcinoma were excluded from this study. 76.4% of the remainder had early-stage diseases (stage I: 14, II: 28, III: 9, and IV: 4). The patients in the years from which they were treated were almost evenly distributed (1st 5 years: 13, 2nd: 14, 3rd: 16, and 4th: 12). There were four treatment groups: external beam radiotherapy (EBRT) alone (n=18), brachytherapy (BT) alone (n=4), EBRT and BT (n=30), and surgery plus RT (n=3). Median follow-up was 50.3 months ranging from 3 to 213 months. 5-year overall survival (OS) was 55.6%, disease-specific survival (DSS) was 77.3%, disease-free survival was 74.2%, and local control was 87.7%. Independent prognostic factors for DSS and OS were tumor stage, site and size (p<0.05). Late radiation toxicity was minimal in the bladder (4.6%) and bowel (4.6%). Vaginal morbidity was observed in 35 patients (63.6%). It was lowest in the BT alone (0%), and highest in the EBRT and BT group (82.1%), especially for those received more th...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L A ManchulG M Thomas
Jan 1, 1989·Acta Obstetricia Et Gynecologica Scandinavica·H MalmströmC Tropé
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Hederman
Jun 1, 1987·Baillière's Clinical Obstetrics and Gynaecology·B G Lindeque
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F DancuartE G Silva
Mar 1, 1985·American Journal of Obstetrics and Gynecology·R N FaireyM Turko
Jun 1, 1982·Gynecologic Oncology·C R Houghton, T Iversen
Oct 1, 1982·Gynecologic Oncology·H G Ball, M L Berman
Nov 1, 1981·British Journal of Obstetrics and Gynaecology·M Al-Kurdi, J M Monaghan
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J PavyH Bartelink
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J J PavyH Bartelink
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyJ Sullivan
May 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·A LeminenP Lehtovirta
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·V ChyleL Delclos
Feb 1, 1996·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R K VyasS Venkatratnam
Sep 10, 1998·Cancer·W T CreasmanH R Menck
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Jul 21, 2000·Australasian Radiology·F ForoudiV Gebski
Jan 6, 2001·The British Journal of Radiology·J A Stryker
Jan 29, 2002·Gynecologic Oncology·Tsutomu TabataKatsuhiko Hasumi
Feb 7, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J L DalrympleL H Smith
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G R OttonA J Crandon
Jul 2, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K HellmanF Pettersson
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·William T Creasman
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Steven J FrankPatricia J Eifel
Nov 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rajiv SamantChoan E
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K HellmanB Frankendal
Sep 19, 2006·The British Journal of Radiology·V S Khoo, D L Joon

❮ Previous
Next ❯

Citations

Apr 5, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P BlecharzW Wysocki
May 13, 2015·The British Journal of Radiology·C S GardnerP R Bhosale
Nov 26, 2010·American Journal of Obstetrics and Gynecology·Andreas BrunnerReinhard Horvat
Aug 4, 2016·Journal of Obstetrics and Gynaecology of India·Chelakkot G PrameelaMakuny Dinesh
Aug 21, 2013·Gynecologic Oncology·Susan M HinikerElizabeth A Kidd
Dec 6, 2014·Critical Reviews in Oncology/hematology·Angiolo GadducciClaudia Sergiampietri
Sep 3, 2014·Female Pelvic Medicine & Reconstructive Surgery·Sarah LeadleyCynthia A Brincat
Nov 1, 2017·International Journal of Clinical Oncology·Hitoshi IkushimaTakafumi Toita
Nov 22, 2017·International Journal of Clinical Oncology·Toshiaki SaitoHidetaka Katabuchi
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tracey S Adams, Mauricio A Cuello
Jul 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Andrea GaluppiPierandrea De Iaco
Jan 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Amol J GhiaDavid K Gaffney
Nov 17, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kristina HellmanGert Auer
Dec 25, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E RomanoF Huguet
Mar 7, 2020·The Lancet Oncology·Henrike WesterveldRemi A Nout
Sep 3, 2009·Current Opinion in Obstetrics & Gynecology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Steven J FrankPatricia J Eifel
International Journal of Radiation Oncology, Biology, Physics
V ChyleL Delclos
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Rajiv SamantChoan E
© 2022 Meta ULC. All rights reserved