Twenty-year trend in mortality among hospitalized patients with pneumococcal community-acquired pneumonia

PloS One
Catia CillónizAntoni Torres

Abstract

There is only limited information on mortality over extended periods in hospitalized patients with pneumococcal community-acquired pneumonia (CAP). We aimed to evaluate the 30-day mortality and whether is changed over a 20-year period among immunocompetent adults hospitalized with pneumococcal CAP. We conducted a retrospective observational study of data that were prospectively collected at the Hospital Clinic of Barcelona of all adult patients hospitalized with diagnosis of pneumococcal CAP over a 20-year period. To aid analysis, results were divided into four periods of 5 years each (1997-2001, 2002-2006, 2007-2011, 2012-2016). The primary outcome was 30-day mortality, but secondary outcomes included intensive care unit (ICU) admission, lengths of hospital and ICU-stays, ICU-mortality, and need of mechanical ventilation. From a cohort of 6,403 patients with CAP, we analyzed the data for 1,120 (17%) adults with a diagnosis of pneumococcal CAP. Over time, we observed decreases in the rates of alcohol consumption, smoking, influenza vaccination, and older patients (age ≥65 years), but increases in admissions to ICU and the need for non-invasive mechanical ventilation. The overall 30-day mortality rate was 8% (95% confidence inte...Continue Reading

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Citations

Mar 14, 2020·Minerva medica·Elena BarbagelataPaolo Solidoro
Jan 4, 2020·The European Respiratory Journal·Carlos J OrihuelaJeremy S Brown
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Dec 10, 2020·Cardiology in the Young·Patrick D EversNicolas L Madsen
Jan 7, 2021·Current Opinion in Pulmonary Medicine·Ignacio Martin-Loeches, Antoni Torres
Apr 10, 2021·Nature Reviews. Disease Primers·Antoni TorresTom van der Poll
Apr 16, 2021·Open Forum Infectious Diseases·Saeed ShoarDaniel M Musher
Nov 17, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Rodrigo B SerafimJorge I F Salluh

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

SPSS Statistics

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